One of the main issues faced with the use of anabolics is the reduction of natural testosterone production of the human body while on cycle and the importance of recovering that natural production once anabolics have been discontinued. The use of anabolics effects the hypothalamic pituitary testicular axis (HPTA) which is the system of organs (the gonads, pituitary gland, and hypothalamus) that regulate testosterone production. The hypothalamus releases a hormone (GnRH), the pituitary gland releases the luteinizing hormone (LH) and the follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone. These processes are all linked. The GnRH is produced to release LH and FSH from the pituitary which in turn stimulate the production of testosterone from the gonads. In males LH is the main stimulant of testosterone production while the FSH is in charge of sperm production. The body has a negative feedback loop that regulates the release of these hormones based on the amount of available testosterone in the system. When the body sees there is sufficient levels of the hormone the HPTA regulates the amount of LH to be released, lowering the secretion of it. With the use of anabolic steroids, the body comes to that point fairly quickly and shuts down LH production, giving us our issue with recovery and a need for post cycle therapy drugs that stimulate LH production.
In anabolic users, hCG (human Chorionic Gonadrotropin) is used to combat the shutdown of LH. hCG mimics the luteinizing hormone (LH) allowing for the user to stimulate the testes for testosterone production, solving the issue of shutdown when on an anabolic cycle or testosterone replacement therapy. hCG is usually prescribed by doctors for testosterone replacement therapy patients or found on the black market for anabolic steroid users. The use of hCG can reduce the recovery time of post cycle therapy since the testes never actually shut down while on cycle. Since studies have shown that the use of testosterone can greatly reduce the natural testosterone levels of the user post cycle, hCG is a valuable tool in recovery and also a valuable tool for maintaining fertility while on trt. In order for post cycle recovery of LH function to occur, your androgenic hormones have to come to a state of balance again by lowering to a level the HPTA is comfortable with, for a lack of better words.
The ideal way to use hCG on cycle is to start with your cycle at 250iu twice a week. I have seen many people use the blast method at the end of cycle before the start of PCT by injecting 1000iu every other day for 2 weeks. I believe this method to be inferior to staying on 500iu a week while on cycle. Recommendations by Dr. Eugene Shippen verify such claims. It has been said that using high amounts of hCG at once desensitizes the testes so the latter philosophy should be king. hCG should be discontinued in PCT since it would interfere with the natural production of LH and has a aromatizing characteristic.
Proper Storage of hCG (credit to cybersage for this idea)
The biggest issue with hCG is its very short shelf life and inability to tolerate heat. The vial has to be kept refrigerated in order to sustain anywhere from 30-60 days shelf life (most prescriptions will only give a 30 day shelf life for hCG). As a testosterone replacement therapy patient myself, I find that my hCG expires long before I get a chance to use it all, wasting my money down the toilet. One of the members on the Steroidology forum had an ingenious idea for extending the shelf life of hCG so it doesn’t go to waste. hCG is usually refrigerated in the same temperatures as food giving it the 30 day shelf life. As with most things, colder temperatures extend shelf life. The shelf life of hCG is doubled when frozen. Cybersage came up with a nifty way to do this.
Here is what you need:
- 1 21-13g needle
- 1 5ml syringe
- A good number of 29g 1/2inch insulin syringes (20 for 5ml should be right).
- Alcohol Swab
Reconstitute your hCG with BAC water so that you are getting 1000iu out of 1ML, that’s the typical dosage (follow proper sterilization protocol).
Take an alcohol swab and swab the top of the vial (do this again, you should have done in it step 1) and remove the total amount of liquid into the 5ml syringe using the 21-23g needle.
Insulin syringe backloading - Have all your insulin syringes out and ready. Remove the plunger of the insulin syringe and with the insulin syringe facing down inject your regular dosage into the syringe (typically 250iu). Barely replace the plunger and let the hCG come all the way down to it when you make the syringe face the ceiling. Push the plunger up to remove all air in the syringe.
Put the insulin syringes that you fill into the freezer.
About 24 hours before you need to inject your hCG transfer the syringe to your regular fridge, it should melt overnight and be ready for injection.
This method is a lifesaver for testosterone replacement therapy clients who see a lot of waste in terms of hCG expiring.
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