Tag Archives: TRT

hcg vila

hCG (human Chorionic Gonadrotropin) Use and Proper Storage

by 3Js Nutrition Network

One of the main issues faced with the use of anabolics is the reduction of natural testosterone production of the human body while on cycle and the importance of recovering that natural production once anabolics have been discontinued. The use of anabolics effects the hypothalamic pituitary testicular axis (HPTA) which is the system of organs (the gonads, pituitary gland, and hypothalamus) that regulate testosterone production. The hypothalamus releases a hormone (GnRH), the pituitary gland releases the luteinizing hormone (LH) and the follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone. These processes are all linked. The GnRH is produced to release LH and FSH from the pituitary which in turn stimulate the production of testosterone from the gonads. In males LH is the main stimulant of testosterone production while the FSH is in charge of sperm production. The body has a negative feedback loop that regulates the release of these hormones based on the amount of available testosterone in the system. When the body sees there is sufficient levels of the hormone the HPTA regulates the amount of LH to be released, lowering the secretion of it. With the use of anabolic steroids, the body comes to that point fairly quickly and shuts down LH production, giving us our issue with recovery and a need for post cycle therapy drugs that stimulate LH production.

hCG milecule

An hCG (human Chorionic Gonadrotropin) molecule

In anabolic users, hCG (human Chorionic Gonadrotropin) is used to combat the shutdown of LH. hCG mimics the luteinizing hormone (LH) allowing for the user to stimulate the testes for testosterone production, solving the issue of shutdown when on an anabolic cycle or testosterone replacement therapy. hCG is usually prescribed by doctors for testosterone replacement therapy patients or found on the black market for anabolic steroid users. The use of hCG can reduce the recovery time of post cycle therapy since the testes never actually shut down while on cycle. Since studies have shown that the use of testosterone can greatly reduce the natural testosterone levels of the user post cycle, hCG is a valuable tool in recovery and also a valuable tool for maintaining fertility while on trt. In order for post cycle recovery of LH function to occur, your androgenic hormones have to come to a state of balance again by lowering to a level the HPTA is comfortable with, for a lack of better words.

The ideal way to use hCG on cycle is to start with your cycle at 250iu twice a week. I have seen many people use the blast method at the end of cycle before the start of PCT by injecting 1000iu every other day for 2 weeks. I believe this method to be inferior to staying on 500iu a week while on cycle. Recommendations by Dr. Eugene Shippen verify such claims. It has been said that using high amounts of hCG at once desensitizes the testes so the latter philosophy should be king. hCG should be discontinued in PCT since it would interfere with the natural production of LH and has a aromatizing characteristic.

hcg vila

Proper storage of hCG will give more life to your supply.

Proper Storage of hCG (credit to cybersage for this idea)

The biggest issue with hCG is its very short shelf life and inability to tolerate heat. The vial has to be kept refrigerated in order to sustain anywhere from 30-60 days shelf life (most prescriptions will only give a 30 day shelf life for hCG). As a testosterone replacement therapy patient myself, I find that my hCG expires long before I get a chance to use it all, wasting my money down the toilet.   One of the members on the Steroidology forum had an ingenious idea for extending the shelf life of hCG so it doesn’t go to waste. hCG is usually refrigerated in the same temperatures as food giving it the 30 day shelf life. As with most things, colder temperatures extend shelf life. The shelf life of hCG is doubled when frozen. Cybersage came up with a nifty way to do this.

Here is what you need:

  • 1 21-13g needle
  • 1 5ml syringe
  • A good number of 29g 1/2inch insulin syringes (20 for 5ml should be right).
  • Alcohol Swab

Step 1

Reconstitute your hCG with BAC water so that you are getting 1000iu out of 1ML, that’s the typical dosage (follow proper sterilization protocol).

Step 2

Take an alcohol swab and swab the top of the vial (do this again, you should have done in it step 1) and remove the total amount of liquid into the 5ml syringe using the 21-23g needle.

Step 3

Insulin syringe backloading - Have all your insulin syringes out and ready. Remove the plunger of the insulin syringe and with the insulin syringe facing down inject your regular dosage into the syringe (typically 250iu). Barely replace the plunger and let the hCG come all the way down to it when you make the syringe face the ceiling. Push the plunger up to remove all air in the syringe.

Step 4

Put the insulin syringes that you fill into the freezer.

Step 5

About 24 hours before you need to inject your hCG transfer the syringe to your regular fridge, it should melt overnight and be ready for injection.

This method is a lifesaver for testosterone replacement therapy clients who see a lot of waste in terms of hCG expiring.

I hope this article was helpful in your quest to your goals. If interested in nutritional and training coaching please contact me at 3jdiet@gmail.com to become a client or click on this link to be transferred to my website www.3jsdiet.com.

androgen receptor

A Word About Testosterone – Part 1: Androgen Therapy

by Ed Barillas, Staff Writer

Androgen drugs can be found in many places. Because they are popular among athletes and bodybuilders, androgen drugs can be found easily in the black market. Physicians also prescribe androgens, legally, for many conditions.

Despite the strong presence of legal and illegal androgen use, the science of androgen effects has greatly lagged behind the understanding of the biological effects of estrogen and indications for estrogen replacement therapy. Female oral contraceptives have been in use for many years, but only recently have we seen studies regarding hormone contraceptive agents in men. Although there are a few very well defined clinical syndromes of male hypogonadism, which requires androgen therapy, their use in other clinical situations, such as mild hypogonadism and hypogonadism associated with aging, is less well known.androgens chart 1

The following should be able to dispel some of the mystery of androgen therapy in older men:

As far as normal androgen physiology, we know that testosterone is present in very low levels in boys prior to puberty.   Once the boy hits puberty a pulsatile secretion of GnRH causes the anterior pituitary to produce LH and FSH. This circulating LH induces the Leydig cells of the testicles to produce testosterone, with the following development of secondary sex characteristics. As the level of testosterone rises in the blood circulation, there is a negative feedback on the production of GnRH at the hypothalamic level, and LH and FSH at the pituitary level.

androgens chart 2A high intra-testicular level of testosterone is an absolute prerequisite for sperm production. The levels in the seminiferous tubules stay high due to the proximity of production in the Leydig cells, and well as by binding in the tubules by androgen binding-protein or ABP. This binding to ABP probably also prevents fluctuation of the levels by maintaining a reservoir of hormone immediately available to buffer changes in production. Although testosterone is the only absolute requirement for sperm production, FSH has a promotional effect and quantitatively normal spermatogenesis requires the action of FSH on the Sertoli cell. When sperm production is proceeding in a quantitatively normal manner, a peptide hormone called inhibin is released into the circulation and by the Sertoli cell, which is responsible for negative feedback of FSH, but not LH production, by the pituitary.

Circulating testosterone is present in several forms. Testosterone may be present as a free hormone, which is not bound to any protein, or bound relatively weakly to albumin. The majority of testosterone in circulation, however, is bound to sex hormone binding globulin or SHBC. The testosterone bound to SHBC is not available for biological activity. Both the free testosterone and that weakly bound to alburnin comprise the so-called “bioavailable” testosterone fraction, which is responsible for peripheral androgenic effects. So the most important measurement in diagnosing hypogonadism, the total T, or free T remains controversial.

Testosterone is converted to other clinically important compounds in the peripheral circulation and/or peripheral tissues. Dihydrotestosterone (DHT) is produced by reduction through the action of 5-reductase, which is ever so present in prostate, skin and the genital tissue. DHT is responsible for prostatic growth and has other trophic effects on the prostatic tissue. Estradiol (E2) is produced by the esterification of testosterone. Its good to note that the rate of conversion of T to E2 can be increased in obese men and in men with liver failure and elevated levels of E2 can bring down the hypothalamic-pituitary-gonadal axis which results in decreased gonadotropin secretion and decreased circulating T levels.

androgen receptor

The androgen receptor bound to testosterone.

As far as changes in testosterone levels, with aging there is no corollary of the menopause seen in females as men age. The menopause in women is caused by ovarian failure. No such similar event of complete testicular failure occurs in men. However, it has been well established that mean T levels drop progressively with age, and the percentage of men with T levels in the abnormal range increases. So when one looks at the levels of bioavailable testosterone (a probably more accurate measure of the decreasing androgenic effects) more marked changes may be evident. Other evidence of a relatively hypogonadal state in older men includes elevated LH, as well as an exaggerated response of LH to the administration of GnRH is staged testing.

Although T levels drop with aging, it is less understood whether any of the generalized manifestations of aging such as osteoporosis, impotence, CNS changes are due to the decrease in circulating androgen. Because it is not established that these age-related changes are due to hormonal deficiencies, the simple presence of a decline in circulating hormones cannot be taken as de facto evidence that hormone replacement therapy will be beneficial in reversing or preventing these changes.

TRT heart

How Testosterone Helps the Heart

by Ed Barillas, Staff Writer

As it is commonly reported in the media that steroids can cause your heart to blow a ventricle, kidneys to implode, and your liver to disintegrate. But is this actually true? Well in reality, the more you learn about steroids, the more you come to realize that, like all drugs, there is a difference between their intelligent use and outright abuse. So we will take a look at the effects of testosterone on the heart and see how these common conceptions hold up.TRT heart

For ages now, we’ve all heard the repeated saying that anabolic steroids are bad for the heart. Some physicians will tell you that testosterone raises your risk of heart disease by lowering your good cholesterol and raising your bad cholesterol. It is also reported that steroids are known to induce an enlargement of the heart or even cardiac hypertrophy.

In reality, the dangers of steroids are overstated and may even be good for the heart.

What are the cardiovascular effects of steroids?

In a recent test, bodybuilders had various aspects of the heart measured such as the carotid intima-media thickness, arterial reactivity, left ventricular dimensions to name a few. These measurements indicate whether bodybuilding, steroid usage, or both affect the shape, function, activity and size of the heart.

The doctors found some obvious and not so obvious results. The bodybuilders who used steroids were physically stronger than those who didn’t and the use of steroids was not found to cause any significant changes or abnormalities of arterial structure or function.

In essence, when both groups of bodybuilders were compared with sedentary controls, any changes in heart function were common to both steroid-using and non-steroid-using bodybuilders. So all said and done, what we learn from this study is that bodybuilding itself can alter, not impair, arterial structure or function and steroids do not appear to impair cardiac function.

TRT heart 2Does MRFIT need a T boost?

The Multiple Risk Factor Intervention Trial (MRFIT) is a study that examined changes in testosterone over a 13 year period in 66 men aged 41 to 61 years. The researchers concluded that changes in total testosterone are related to cardiovascular disease risk factors.

The average testosterone levels at the beginning of the study were 751 ng/dl and decreased by 41 ng/dl. Also, men who smoked or exhibited Type A behavior were found to have even greater decreases in T levels. The change in testosterone was also associated with a decrease in in the good cholesterol and an increase in triglyceride levels.

The conclusion stated that decreases in testosterone levels as observed in men over time are associated with unfavorable heart disease risk.

In a similar study, researchers in Poland examined if testosterone replacement therapy in aging men positively affected heart disease risk factors. It noted that twenty-two men with low T levels received 200 mg of testosterone enanthate every other week for one year. Throughout this treatment, total cholesterol, testosterone, estradiol, LDL and HDL were measured. The researchers concluded that T replacement returned both testosterone and estradiol levels back to normal and normal levels. They also found that T replacement lowered cholesterol and LDL, which is the bad cholesterol without altering HDL, which is the good cholesterol and there was no change in prostate size or function.

This study proved that T replacement doesn’t appear to raise heart disease risk – and it may actually lower your risk. There are many physicians out there today that should be prescribing low dose testosterone to middle age and aging men for muscle tone, both libido and for cardiac reasons.

It’s been long shown and proved that men have a higher risk of heart disease. One of the risk factors implicated is testosterone. The recreational use of testosterone can alter lipoprotein levels and in many cases reports exist that describe bodybuilders who’ve abused steroids and have experienced heart disease or even sudden death. But one can still ask, is the causal association one of truth or just an association? Well, researchers at the University of North Texas recruited twelve competitive bodybuilders for a comprehensive evaluation of the cardiovascular effects of steroids. Six heavyweight steroid-using bodybuilders were compared with six heavyweight drug-free bodybuilders.

And sure enough the heavy steroid users had lower total cholesterol and HDL levels as compared to the drug-free athletes. What was unexpected was that the steroid users also had significantly lower LDL and triglyceride levels as compared to the non-steroid users. In addition, the juicers also had lower Apo-lipoprotein B levels, which is a marker for heart disease risk. Thus, the authors concluded that androgens do not appear to raise the risk of cardiovascular disease. Thus the conclusion of this study is that the negative cardiac side effects of steroids are most likely overstated.

We know that as we age, circulating testosterone levels naturally decrease. For most men, the testosterone decrease goes from high normal to mid to low normal. There is also data that shows that there’s an inverse relationship between T levels and blood pressure as well as abdominal.

Testosterone replacement lowers abdominal obesity and restores testosterone levels back to normal. Positive side effects of restored testosterone is correlated with stronger sex drive, better mood, lower cardiovascular, disease risks, better muscle tone, stronger bones and improved memory. It should also be noted that while conservative use gives a pronounced positive health benefit, higher doses might not necessarily lead to further health benefits.

 

 

 

 

androgel

Sloppy TRT Studies Lead to Lawsuit Threats

Citing two recent studies that concluded that testosterone replacement therapy (TRT) leads to a greater risk of heart attack and other cardiovascular diseases, lawyers groups have begun looking into filing class action lawsuits against the top makers of TRT products, such as Androgel, Axiron, Fortesta and more.

The most recent study linking TRT to heart disease was conducted by William Finkle and Associates and published in the journal Plos One. The study, which was released on Jan. 29, said it found evidence of increased risk of heart attack for testosterone users and even greater risk for those users who already had a history of cardiovascular disease. The study was’s findings were similar to a study published in the Journal of the American Medical Association in November of last year that looked at patients of VA hospitals that were undergoing TRT. Just two days after the Plos One study was released, the FDA issued a statement saying it was going to investigate the risks of TRT.

androgel

The makers of Androgel are facing possible class action lawsuits based off of two questionable studies.

Almost immediately after the FDA warning, lawyers from across the country began a fishing expedition to find clients who may have been had heart problems and who underwent TRT or family members of men who died with on TRT. A quick Google search for TRT lawsuits will reveal pages of hits for lawyers ready to sue the pants off TRT drug makers. There are even television commercials airing that are searching for people to join the suit. It is unclear how many people have yet to sign on to these lawsuits and even the language the lawyers are using to attract people to sue seem vague and ambiguous, using terms like “…investigating claims financial compensation…” or “…likelihood of an Androgel class action lawsuit in the near future is very high…”

What is clear, however, is that the studies used to prompt action by the FDA and the trial lawyers are far from solid in their methodology. In an article written for the Huffington Post, Dr. Jen Landa M.D. pointed out that the conclusions of both the Plos One and JAMA studies are essentially meaningless because of the flawed nature in which they were held.

“Neither study assessed testosterone levels of patients before and during therapy. There are other critical blood tests that should be done that were not being done during the treatment of the VA men or in the current study, including blood counts and estrogen levels. Higher red blood cell counts and higher estrogen levels are known issues that may occur in men given testosterone therapy. Without assessment of testosterone levels, red blood cell counts and estrogen levels prior to and during therapy, it is impossible to tell if a patient is a proper candidate for therapy and if they are tolerating the therapy well.”

TRT lawsuit

Ads like this one are fishing for TRT patients to join class action lawsuits, despite the lack of evidence that TRT causes cardiovascular disease.

In addition, the Plos One study compared men who were taking ED drugs like Viagra or Cialis to ones who were on testosterone under the assumption that both groups would be equally sexually active. This gave the patients on the ED drugs an advantage in not having cardiovascualr problems because of the positive effects these drugs have on relaxing blood vessels and easing pulmonary hypertension.

According to Todd Thomas, owner and operator of Increase My T, a clinic that specializes in TRT, the doctors in the study were not following some of the most important protocols that TRT clinics like his own would follow.

“Testosterone effects people differently, which is why it is important to titrate the dosages appropriately,” he said.  The doctors in the study were giving too much testosterone to the patients – 22 mg injections.  If some of the patients were overweight, they should have adjusted the dose accordingly. “Also, the study noted there were patients who had high estrogen levels but none of the doctors gave those patients aromatose inhibitors. Estrogen leads to water retention that can have adverse effects on blood pressure.”

Thomas was also quick to point out that the Plos One study only looked at patients during the first 90 days of their TRT, which raises questions as to how lawyers think they can use this study as a basis for suing manufacturers of topical TRT patches like Androgel.

“Androgel, because of its low doses, can take up to six months for testosterone to get up to 600 ppm in the blood stream. So using a study that followed patients for three months to base lawsuit on is ridiculous,” he said.

Both Thomas and Dr. Landa see similarities in these poorly researched studies to ones that were conducted on the use of hormone replacement in women to ease the effects on menopause. Just when hormone replacement was showing signs of helping women, some poor practices by doctors and studies that only looked at the patients of those doctors scared women into believing that hormone replacement would lead to ovarian cancer.

“Back then, and as with this study, doctors would overprescribe the medication and then not follow up,:” Thomas said. “It was like, ‘here’s an unlimited prescription, come back and see me in eight months.’”

Despite the findings of the two studies and the FDA warning, Thomas insists that TRT is safe for elderly men if doctors and patients follow the correct protocols. He suggests that elderly men: start with low doses; monitor all testosterone and estrogen levels; get a comprehensive metabolic screening; get a full cholesterol and lipids screening; and monitor diet and weight.

“Safety is tied to monitoring and that’s the bottom line. People who monitor have longer, safer and better results from TRT.”

 

The Testopel pellets are quite small and slowly dissolve over the 3 months.

Testopel, the ideal testosterone replacement

by Dr Gary Bellman, Board Certified Urologist, Member Academy of Anti-Aging Medicine.

The first question is if testosterone replacement is right for you. If the answer is yes then the next question is what is the best method. The methods that I have used include topical gels and creams, injections and pellets. Over the last number of years I have been underwhelmed with the results with the topical application of testosterone. Unfortunately many men do not absorb the gel or cream well. In addition these products can be smelly and sticky as well as expensive and carry the risk of transferring the testosterone to a partner. Injections work well, however they need to be administered weekly or sometimes twice a week.

In addition, as men are a rather non-compliant group, many men skip applications of testosterone and thus the levels fall. The goal of testosterone replacement is to maintain steady levels to achieve the best results.

I now prefer the placement of testosterone pellets, called Testopel. These tiny pellets are placed under the skin and maintain excellent levels of testosterone for 3 months.

The placement takes 3-4 minutes in the office with no suturing and is relatively painless. This allows men who are interested in testosterone replacement to come to the office 4 times a year and don’t need to worry about anything else.

Testopel may be the ideal method of testosterone replacement.

The Testopel pellets are quite small and slowly dissolve over the 3 months.The skin is quickly numbed with a local anesthetic.

A row of pellets are placement under the skin.

The skin is quickly numbed with a local anesthetic.

The small trocar (tube) is placed through a tiny puncture in the skin and the pellets are carefully placed.

The pellets are placed under the skin and fat layer and generally are not felt.

After the procedure there is a tiny puncture of the skin that heals in a few days without suturing.

Small strips are placed over the site with no recovery needed.

Every man has different needs as far as his dose on the number of pellets. It depends on one’s age, body size and level of activity. I generally start around 12 pellets but for younger more active guys up to 16 or even higher may be necessary. Blood tests after 2 months of the pellet insertion helps guide the dose for the next insertion. It is important to check not only the testosterone levels but the estradiol (female hormone) as well as the blood count (CBC) and PSA (prostate).

 


Dr. Gary Bellman, M.D., is a Board Certified Urologist, interested in Testosterone replacement and men’s heath. He attended medical school at McGill University, did a fellowship at Long Island Jewish Medical Center and has taught at UCLA for many years. He is currently is private practice in the San Fernando Valley, a suburb of Los Angeles.

For more information on Dr. Bellman, visit his Websites: http://www.drgarybellman.com/

http://www.uroantiaging.com/

For questions or other inquiries, you may contact Dr. Bellman at gburomd@yahoo.com.