Active Life: 5-7 days
Drug Class: Selective Estrogen Receptor Modulator (Oral)
Average Dose: 10-30 mg/day
Acne: Yes
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: low
Nolvadex®, is the trade name for the drug tamoxifen citrate,
it is a non-steroidal agent that demonstrates potent anti-estrogenic
properties. The drug is technically an estrogen agonist/antagonist,
which competitively binds to estrogen receptors in various target
tissues. With the tamoxifen molecule bound to this receptor, estrogen
is blocked from exerting any action, and an anti-estrogenic effect
is achieved. Since many forms of breast cancer are responsive to estrogen,
the ability of tamoxifen citrate to block its action in such cells
has proven to be a very effective treatment. It is also utilized successfully
as a preventative measure, taken by people with an extremely high
familial tendency for breast cancer. While Nolvadex is effective against
estrogen, it is not our strongest available remedy. We now have the
drugs Arimidex, Femara, and Aromasin available to us, which notably
prevents estrogen from being manufactured in the first place. Altering
the effect of estrogen in the female body can cause a level of discomfort,
so anti-estrogens are most bearable when used after the point of menopause.
Since Nolvadex is milder in comparison, it is more widely applicable
and usually the first treatment option.
As discussed earlier, an enzyme in the male body (aromatase) is capable
of altering testosterone to form estradiol. The structure of estrogen
is actually quite similar to testosterone, so its presence in the
male body is not all that remarkable. Since this same enzyme can also
aromatize many anabolic/androgenic steroids, the buildup of estrogens
can be an important concern during intake. High levels can cause a
number of unwanted side effects, a primary worry being gynecomastia
or the development of female breast tissue in men. This can be first
noticed by the appearance of swelling or a small lump under the nipple.
If left to progress it can turn into a very unsightly development
of tissue, often irreversible without surgery. Estrogen can also lead
to an increase in the level of water retained in the body. The result
here can be a notable loss of definition, the muscles beginning to
look smooth and bloated due to the retention of subcutaneous fluid.
Fat storage may also be increased as estrogen levels rise. This hormone
is in fact the primary reason women have a higher body fat percentage,
and different fat distribution (hips/thighs) than men. Individuals
sensitive to the effects of estrogen will usually be sure to have
an anti-estrogen on hand when taking problematic steroids, so as to
minimize the impact of related side effects.
This drug also shows the ability to increase production of FSH (follicle
stimulating hormone) and LH (luteinizing hormone) in the male body.
This is accomplished by blocking negative feedback inhibition caused
by estrogen at the hypothalamus and pituitary, which fosters the release
of the mentioned pituitary hormones. This of course is also the function
of Clomid and cyclofenil. Since a higher release of LH can stimulate
the Leydig's cells in the testes to produce more testosterone, Nolvadex
can have a positive impact on one's serum testosterone level. This
"testosterone stimulating" effect is an added benefit when
preparing to conclude a steroid cycle (post cycle therapy or PCT).
Since most anabolic/androgenic steroids will suppress endogenous testosterone
production, Nolvadex can help restore a balance in hormone levels.
Nolvadex should be preferred over Clomid for this purpose in fact,
as side by side it is clearly the stronger agent. It has also been
shown to increase LH responsiveness to Gonadotropin Releasing Hormone
after time, while Clomid slightly lowers this sensitivity as the drug
is used for several weeks..
In some cases the use of only an estrogen antagonists such as Nolvadex
or Clomid may be sufficient for testosterone stimulating purposes,
particularly when halting the use of a milder or shorter steroid program
(which should have a less pronounced impact on the hormonal system).
With stronger cycles most option to enhance the stimulating effect
of these drugs with HCG, a hormone that mimics the action of LH. HCG
use provides an excessive level of stimulation to the testes, which
in essence may shock them out of a prolonged state of inactivity.
In such a condition the Leydig's cells may not be producing a normal
amount of testosterone, even though the normal release of gonadotropins
has been achieved. Nolvadex can be tricky at this point. Remember
it only blocks the effect of estrogen that is present in the body.
If it is removed at a time when estrogen levels are still unusually
high, related side effects can quickly become a pronounced problem.
Since HCG not only increases the production of testosterone but also
enhances the rate of aromatization in the testes, anti-estrogens should
not be discontinued until at least a couple of weeks after HCG is
discontinued. The result otherwise of course could be many unwanted
side effects that were previously under control. When using Nolvadex
to ward off the effects of estrogen during the cycle, it should similarly
not be removed until the user is confident that hormone levels are
well under control. With a drug such as Sustanon, this may mean continuing
it for several weeks after the last shot.
A typical daily dosage for men is in the range of 10 to 30mg, the
amount would be dependent on the level of effect desired. It is advisable
to begin with a low dosage and work up, to avoid taking an unnecessary
amount. The time in which Nolvadex is started also relies on individual
needs of the user. If an athlete with a known sensitivity to estrogen
is starting a strong steroid cycle, Nolvadex should probably be added
soon after the cycle had been initiated. If estrogen is probably not
going to be a major problem during the cycle (but will likely be after),
Nolvadex is administered around the time exogenous steroid levels
will drop. It will be continued for some weeks after, until the point
when natural testosterone is thought to be at an acceptable level.
As mentioned HCG is often used at this point as well (see related
profile for more detail). Women have also utilized Nolvadex in an
effort to reduce the effect of their own endogenous estrogens. This
can lower body fat concentrations, especially in stubborn areas like
the hips and thighs. This is of course risky, as manipulating the
effect of estrogen can become uncomfortable in women. Side effects
like hot flashes, menstrual irregularities and a variety of complications
with the reproductive system are all possible.
When looking for a stronger anti-estrogenic effect, Proviron can
make a good addition to Nolvadex. Although this compound is technically
an androgen, it may have a pronounced effect on the production of
estrogen in the body. Its mode of action is therefore very different
than that of Nolvadex. While Nolvadex only blocks the binding ability
of free-floating estrogen, Proviron can minimize the creation of it.
With each drug attacking estrogen via a different mechanism, we have
a very synergistic combination. A daily intake of 20-30mg Nolvadex
and 25-50mg Proviron can be extremely effective when dealing with
a strong estrogenic cycle. Women often avoid adding Proviron to Nolvadex
treatment (thought often it is still used to enhance fat loss), for
fear of developing virilization symptoms (Proviron is an oral DHT).
Virilizing effects can occur very quickly once there has been a dramatic
rise in the activity of androgens (intensified by a decrease in estrogen
activity), so at a minimum women should be careful with such a combination.
Of great interest also is that Nolvadex is an estrogen agonist in
the liver, capable of activating the estrogen receptor and mimicking
the actions of this sex hormone in this region of the body. As such
it can have a markedly positive impact on HDL (good) cholesterol values,
as does estrogen. Many similarly use this drug to counter some of
the negative consequences of steroid use in regards to cholesterol
values and cardiac risk, as steroids often suppress HDL and raise
LDL levels considerably. in some instances an athlete is able to maintain
a very favorable HDL/LDL cholesterol ratio, to spite the use of a
moderate dosage (400mg weekly) of an injectable like testosterone
or nandrolone. It would be foolish to think however that Nolvadex
would be a sufficient remedy with the heavy use of c-l7alpha alkylated
orals or extremely high dosed cycles in general.
It has been reported by many however that Nolvadex seems to slightly
reduce to gains made during a steroid cycle. It appears that many
androgenic/anabolic steroids will exhibit their most powerful anabolic
effect when accompanied by a sufficient level of estrogen. This may
be one reason why gains made with a strong androgen like testosterone
are usually much more pronounced than when using an anabolic that
aromatizes to a lower degree. It therefore seems like good advice
to be aware of how much Nolvadex is actually needed before committing
to it during a cycle. Many people in fact find it unnecessary, even
when utilizing problematic compounds such as testosterone or Dianabol.
Others however find they are troubled by water retention and gynecomastia,
even with milder anabolics like Deca-Durabolin and Equipoise. The
estrogenic response to steroid use is very individual, and may be
influenced by factors such as age and body fat percentage (adipose
tissue is a primary site of aromatization).
Nolvadex is certainly the most popular anti-estrogen used by athletes
today, no doubt because it is simply an effective product. It is also
widely manufactured, and easy to obtain. Since there never seems to
be a lack of supply, there is little incentive to manufacture a counterfeit
product. All of the various generics forms of this drug are no doubt
trustworthy. Women should remember to be very cautious when considering
the use of Nolvadex, as they are usually very sensitive to changes
in the activity of estrogen. Men looking for a stronger anti-estrogenic
effect may want to consider using Arimidex, Femara, or Aromasin ,
three powerful new anti-aromatase compounds. They are much more effective
for estrogen control.
Steroid Profiles - Nolvadex® (tamoxifen Citrate) - Steroidology.com