One of the major issues of bodybuilders is gynocomastia prevention, reversal, using letrozole and anti-estrogens. To understand how gynocomastia is caused and how to deal with it, first you must familiarize yourself with some basic terms.
Selective estrogen receptor modulators (SERMS) are drugs that bind to estrogen receptors, making it more difficult for estrogen to bind to them and cause estrogen related side effects. Some of the most common SERMs are Nolvadex (tamoxifen) and Clomid (clomiphene)
Aromatose nhibitors are drugs that work to keep androgens from converting into estrogen which also keeps estrogen from binding to estrogen receptors. Popular aromatose inhibitors include Anastrozole (l-dex, a-dex), Femara (letrozole) and Aromasin (exemestane).
Letrozole is the most powerful aromatose inhibitor you can use during a cycle. It will inhibit more that 98 percent of estrogen, even at doses as low as .25 mgs. Doses of .5 mgs are not recommended during a cycle to prevent estrogen side effects. To stabalize the blood, begin using letrozole at least two weeks before you begin your cycle. Also, if you are using letrozole it is not necessary to use another aromatose inhibitor or SERM.
If you are using a SERM like Nolvadex as your estrogen suppressor and you develop gynocomastia, recognizable by the development of a hard lump behind your nipples, begin using letrozole immediately.
If you are using another anti-estrogen and you start to develop gynocomastia, follow this formula. On day one, take the anti-estrogen and .25 mgs of letrozole. On day two, take only .5 mgs of letrozole. Then add .50 mgs of letrozole every day for four more days. Then remain taking letrozole at 2.5 mgs per day until the gynocomastia is gone usually about 5 to 7 more days.
If you are already using letrozole and you develop gynocomastia, add .50 mgs of letrozole per day for six days. Day one would be .5 mgs, day two 1.0 mgs, day three 1.5 mgs, etc. Again, take the letrozole at a dose of 2.5 mgs per day for 5 to 7 more days to ensure that the gynocomastia has reversed.
If you are not using any kind of estrogen suppression, begin taking .5 mgs of letrozole and add .5 mgs per day for six days until you are at a daily dose of 2.5 mgs which you will need to take for 5 to 7 more days.
After you’ve built up your dose and held it steady at 2.5 mgs per day, you will need to slowly reverse the dose down by .5 mgs per day and a final day of .25 mgs.
When your body is completely estrogen free, it will begin to rebound its natural levels and over compensate for the loss. This is why you should begin taking a SERM such as Nolvadex on your last day of taking letrozole during your cycle as part of your post cycle therapy.