Hey Rich..
I feel ya!! I have been going through the same shit with my mother these past 2 months!! only she is 62.. was prescribed ambien and ambien cr.. they do work for her.. knock her out but when she doesn't take them, she gets no sleep..
at 62, my mom's melatonin production and gh are nil.. your wife's however should be working

you may want to get her levels tested.. also how are her seratonin levels?
One of the leading causes to interrupted sleep is STRESS!!! how is your wife handling her stress and anxiety?? from what you wrote, it seems like they may be the culprit!! try some yoga

Also, YES the combination of the nova & var could be doing it as i am sure her hormones are NOT balanced right now... My best friend is on the ring and it took her body about 3 months will a shitload of problems until her body finally adjusted and even now, 1 yr later, if she leaves it in too long, she gets a month of problems... so hormone manipulation is a BITCH!!!
ok so here are some solutions that my mom has been trying and seem to help.. not a cure but are helping.. maybe in time it will be a cure..
1) a sound machine with consistent white noise.. when we are sleeping in dead silence, any noise can break our sleep thus causing rewaking throughout the night.. a consistent noise with 0 inflection can help keep us in a state of consistent sleep
2) melatonin
3) seratonin (5htp, st. johns wart)
4) 1 hour prior to sleeping, she needs to start relaxing! active relaxing! That means no stress...
5) an orgasm a day brings sleep right away

shit, always knocks me out lol..
also something to consider... what stimulants is she taking: caffeine, fat burners, B vitamins! My mother actually had to stop taking vitamins with B in them as she was getting restless leg and the B was making her too anxious..
well.. i hope this has helped get you started and put some ideas in your head! Good luck!!
luv supes