TRT - how long until I feel the effect(s)
Thought this excerpt would be of interest to those who are just starting (restarting) HRT.
ONSET OF EFFECTS OF TESTOSTERONE TREATMENT AND TIME SPAN UNTIL MAXIMUM EFFECTS ARE ACHIEVED.
Eur J Endocrinol. 2011 Jul 13;
Authors: Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ
Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone repla***ent therapy from their first manifestation until maximum effects are attained.
Design: Studies in PubMed on testosterone repla***ent so far providing information on time course.
Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
Changes in erections/ejaculations may require up to 6 months.
Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
First effects on erythropoiesis after 3 months, peaking at 9-12 months.
Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
Effects on lipids appear after 4 weeks, maximal after 6-12 months.
Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
Effects on inflammation occur within 3 to 12 weeks.
Effects on bone detectable after 6 months but continue at least for 3 years.
Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.
PMID: 21753068 [PubMed - as supplied by publisher]