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B Vitamins.

  1. #1
    A Legend bleachcola's Avatar
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    Default B Vitamins.
    I remember hearing something about B vitamins competing with each other for absorption and excretion in the body. Can someone elaborate on it? My interest is aroused on the fact that I am trying out Niacin for lipid profiles and believe I should discontinue my use of a multi that has large amounts of B vitamins in it. I fear they may inhibit the absorption and increase the excretion of the Niacin. Thanks.

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    Community Veteran DADAWG's Avatar
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    Quote Originally Posted by bleachcola
    I remember hearing something about B vitamins competing with each other for absorption and excretion in the body. Can someone elaborate on it? My interest is aroused on the fact that I am trying out Niacin for lipid profiles and believe I should discontinue my use of a multi that has large amounts of B vitamins in it. I fear they may inhibit the absorption and increase the excretion of the Niacin. Thanks.
    ive never heard that about b vitamins and ive studied vitamins a good bit . how much niacin are you takeing and what kind ?
    NOT ONLY IS STUPIDITY INCURABLE BUT ITS ALSO CONTAGIOUS OVER THE INTERNET.

    VAR ONLY CYCLES ARE ONLY FOR PEOPLE WITH A VAGINA.

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    A Legend bleachcola's Avatar
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    Quote Originally Posted by DADAWG
    ive never heard that about b vitamins and ive studied vitamins a good bit . how much niacin are you takeing and what kind ?
    Taking the flush free kind at 500mg in the morning and 500mg at night. Slowly working my way up in doses. How much do people really need to take to see lipid benefits? And at what point does liver stress occur? I've seen conflicting answers.

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    Community Veteran DADAWG's Avatar
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    Quote Originally Posted by bleachcola
    Taking the flush free kind at 500mg in the morning and 500mg at night. Slowly working my way up in doses. How much do people really need to take to see lipid benefits? And at what point does liver stress occur? I've seen conflicting answers.
    theres more info put there about niacin , than flush free naicin . i wouldnt go any higher than you are imo , if its not working by then , its probablly not going to . you would be surprised but a lot of people could tolerate regular niacin well if they SLOWLY built up their doses . i know a small older lady who can take 1 gram ed comfortablly unless she misses a day or 2 than the red face comes back lol . just dont miss those doses when you build up your tolerance .
    NOT ONLY IS STUPIDITY INCURABLE BUT ITS ALSO CONTAGIOUS OVER THE INTERNET.

    VAR ONLY CYCLES ARE ONLY FOR PEOPLE WITH A VAGINA.

  5. #5
    A Legend bleachcola's Avatar
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    Yeah, I heard something about the flush free variety not being as effective.

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    i take 100mg of the flush niacin 4 times ed and the only time i notice any flush effect is on meals were my fat intake is not very high and carbs are.

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    Olympian Bodybuilder Miss Muscle's Avatar
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    So do you think I should be taking a Niacin supplement? What exactly does it do and why take it? What foods have niacin naturally? You guys have me curious now.

  8. #8
    A Legend bleachcola's Avatar
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    Quote Originally Posted by Miss Muscle
    So do you think I should be taking a Niacin supplement? What exactly does it do and why take it? What foods have niacin naturally? You guys have me curious now.
    Lowers LDL and raises HDL. Won't be able to get enough from food to see a difference, have to supplement for that effect.

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    Eze
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    I take 3g per day and I don't get any flushing or any bad effects from it (that I can tell). I also take Red Yeast Rice for the HDL/LDL as well.

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    http://www.umm.edu/altmed/ConsSupple...3Niacincs.html

    Vitamin B3 (Niacin)

    Overview

    Vitamin B3, also called niacin, is one of eight water-soluble B vitamins. All B vitamins help the body to convert carbohydrates into glucose (sugar), which is "burned" to produce energy. These B vitamins, often referred to as B complex vitamins, are essential in the breakdown of fats and protein. B complex vitamins also play an important role in maintaining muscle tone along the digestive tract and promoting the health of the nervous system, skin, hair, eyes, mouth, and liver.

    Niacin plays an important role in ridding the body of toxic and harmful chemicals. It also helps the body make various sex and stress-related hormones in the adrenal glands and other parts of the body. Niacin is effective in improving circulation and reducing cholesterol levels in the blood. Niacin needs can be partially met by eating foods containing protein because the human body is able to convert tryptophan, an amino acid, into niacin.

    Dietary deficiency of niacin tends to only occur in areas of the world where people eat corn as a staple and don't use lime in fertilization. Corn is the only grain that is low in niacin. Lime releases tryptophan which, again, can be converted to niacin in the body. Symptoms of mild deficiency include indigestion, fatigue, canker sores, vomiting, and depression. Severe deficiency of both niacin and tryptophan can cause a condition known as pellagra. Pellagra is characterized by cracked, scaly skin, dementia, and diarrhea. It is generally treated with a nutritionally balanced diet and niacin supplements. Niacin deficiency also results in burning in the mouth and a swollen, bright red tongue In the United States alcoholism is the prime cause of Vitamin B3 deficiency.


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    Uses

    Extremely high doses of niacin (available by prescription) have been shown to prevent and/or improve symptoms of the following conditions. Because of risk of toxicity people should always consult a knowledgeable health care provider before starting high doses of niacin.

    High Cholesterol
    Niacin is commonly used to lower elevated LDL ("bad") cholesterol and triglyceride (fat) levels in the blood and is more effective in increasing HDL ("good") levels than other cholesterol-lowering medications. However. High doses of niacin produce the side effects of flushing of the skin (which can be reduced by taking aspirin 30 minutes before the niacin), stomach upset (which usually subsides in a few weeks), headache, dizziness, blurred vision, and liver damage. Although the time-release form of niacin reduces flushing, long-term use is associated with liver damage.

    Atherosclerosis
    High doses of niacin medications are used to prevent development of atherosclerosis (plaque along the blood vessels that can cause blockage) and to reduce recurrent complications such as heart attack and peripheral vascular disease (atherosclerosis of the blood vessels in the legs that can cause pain with walking, called intermittent claudication) in those with the condition. According to a review of major clinical trials, the use of niacin for prevention and treatment of atherosclerosis and related conditions is "based on strong and consistent evidence" and appears to be as effective as certain medications for heart disease. Studies also suggest that high dose niacin may help relieve the symptoms of claudication namely diminish the pain experienced with walking.

    A recent study also found that the combination of niacin and a cholesterol-lowering drug called simvastatin (which belongs to a class known as HmG CoA reductase inhibitors or statins) may dramatically slow the progression of heart disease, reducing risk of heart attack, and even death.

    Diabetes
    Because diabetes is often associated with atherosclerosis and heart disease, people with diabetes may benefit from nutrients that help manage elevated cholesterol levels and high blood pressure. Although niacin has been shown to boost HDL cholesterol and decrease triglyceride and LDL levels, there has been some concern that it may also raise blood sugar levels. In a recent study of 125 people with diabetes and 343 people without the condition, high doses of niacin (roughly 3000 mg/day), increased blood sugar in both groups, but hemoglobin A1C (considered a better measure of blood sugar over time) actually decreased in the diabetes group over a 60-week follow-up period. For this reason, if you have diabetes, niacin should only be used under the close monitoring of a qualified health care provider.

    Osteoarthritis
    Some preliminary studies suggest that vitamin B3, as niacinamide, may improve arthritis symptoms, including increasing joint mobility and reducing the amount of anti-inflammatory medications needed. Researchers speculate that niacinamide may aid cartilage repair (damage to joint cartilage causes arthritis) and suggest that it may be used safely along with NSAIDs (non-steroidal anti-inflammatory medications) to reduce inflammation. Further research is needed to fully understand how vitamin B3 benefits people with OA and to determine whether the results apply to large numbers of people with the condition. It does appear, however, that niacinamide must be used for at least 3 weeks before the benefits described are seen. Experts also suggest that long-term use (1 to 3 years) may slow the progression of the disease.

    Cataracts
    Dietary vitamin B3, along with other nutrients is important for normal vision and prevention of cataracts (damage to the lens of the eye which can lead to cloudy vision.) One study including 2900 people living in Australia found that people who consumed the most protein, vitamin A, and vitamins B1 (thiamine), B2, and B3 (niacin) in their diets were significantly less likely to develop cataracts. A follow-up study also found that many supplemental B complex vitamins (including B12, B9, B3, B2, and B1) exert a protective effect against cataracts.

    Burns
    It is especially important for people who have sustained serious burns to obtain adequate amounts of nutrients in their daily diet. When skin is burned, a substantial percentage of micronutrients may be lost. This increases the risk for infection, slows the healing process, prolongs the hospital stay, and even increases the risk of death. Although it is unclear which micronutrients are most beneficial for people with burns, many studies suggest that a multivitamin including the B complex vitamins may aid in the recovery process.

    Other
    An interesting area of research currently underway is the use of niacin skin care products as anti-aging agents, for treatment of acne, and, possibly, for prevention of skin cancer. Dermatologists expect that there will be information emerging about topical forms of niacin for these purposes over the next few years.


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    Dietary Sources

    The best dietary sources of vitamin B3 are found in beets, brewer's yeast, beef liver, beef kidney, pork, turkey, chicken, veal, fish, salmon, swordfish, tuna, sunflower seeds, and peanuts.


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    Available Forms

    Niacin is available in several different supplement forms: niacinamide, nicotinic acid, and inositol hexaniacinate. The form of niacin that is best tolerated with the least symptoms is inositol hexaniacinate. Niacin is available as a tablet or capsule in both regular and timed-release forms. The timed-release tablets and capsules may have fewer side effects than the regular niacin; however, the timed-release are more likely to cause liver damage and are therefore not recommended for long-term treatment. Regardless of the form of niacin being used, periodic checking of liver function tests is recommended when high-dose (2 6 gm per day) of niacin is used.


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    How to Take It

    Daily requirements for niacin may be higher for those who have cancer, those who are being treated with isoniazid (for tuberculosis), and people with protein deficiencies.

    Daily recommendations for niacin from the diet for healthy individuals are listed below.

    It is important to note, however, that only extremely high doses of niacin (in the range of 1,500 to 3,000 mg per day in divided doses) are helpful for most medical conditions. Such high doses are considered "pharmacologic" and must be prescribed by a qualified healthcare practitioner. The practitioner will instruct you on increasing the amount of niacin slowly, over the course of 4 to 6 weeks, and to take the medicine with meals to avoid stomach irritation.

    Pediatric

    Infants birth to 6 months: 2 mg (adequate intake)
    Infants 7 months to 1 year: 4 mg (adequate intake)
    Children 1 to 3 years: 6 mg (RDA)
    Children 4 to 8 years: 8 mg (RDA)
    Children 9 to 13 years: 12 mg (RDA)
    Males 14 to 18 years: 16 mg (RDA)
    Females 14 to 18 years: 14 mg (RDA)
    Adult

    Males 19 years and older: 16 mg (RDA)
    Females 19 years and older: 14 mg (RDA)
    Pregnant females: 18 mg (RDA)
    Breastfeeding females: 17 mg (RDA)


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    Precautions

    Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable healthcare provider.

    High doses (75 mg or more) of niacin can cause side effects. The most common side effect is called "niacin flush," which is a burning, tingling sensation in the face and chest, and red or "flushed" skin. Taking an aspirin 30 minutes prior to the niacin may help reduce this symptom.

    At the very high doses used to lower cholesterol and the other conditions mentioned previously, liver damage and stomach ulcers can occur. When taking pharmacologic doses of niacin, your doctor or other healthcare practitioner will periodically check your liver function through a blood test. People with a history of liver disease or stomach ulcers should not take niacin supplements. Those with diabetes or gallbladder disease should do so only under the close supervision of a healthcare provider. Niacin should not be used if you have gout.

    Taking any one of the B complex vitamins for a long period of time can result in an imbalance of other important B vitamins. For this reason, it is generally important to take a B complex vitamin with any single B vitamin.


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    Possible Interactions

    If you are currently being treated with any of the following medications, you should not use niacin without first talking to your healthcare provider.

    Antibiotics, Tetracycline
    Niacin should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Niacin either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

    Aspirin
    Taking aspirin before taking niacin may reduce flushing associated with this vitamin. This should only be done under the advice of a healthcare practitioner.

    Blood Pressure Medications, Alpha-blockers
    When niacin is taken with certain blood pressure medications known as alpha-blockers (such as prazosin, doxazosin, and guanabenz), the likelihood of side effects from these medications is increased.

    Cholesterol-lowering Medications
    Niacin binds bile-acid sequestrants (cholesterol-lowering medications such as colestipol, colesevelam, and cholestyramine) and may decrease their effectiveness. For this reason, niacin and these medications should be taken at different times of the day.

    As described earlier, recent scientific evidence suggests that taking niacin with simvastatin (a drug that belongs to a class of cholesterol-lowering medications known as HMG-CoA reductase inhibitors or statins including atorvastatin and lovastatin as well), appears to slow down the progression of heart disease. However, the combination may also increases the likelihood for serious side effects, such as muscle inflammation or liver damage.

    Diabetes Medications
    People taking insulin, metformin, glyburide, glipizide, or other medications used to treat high blood sugar levels should monitor their blood sugar levels closely when taking niacin supplements.

    Isoniazid (INH)
    INH, a medication used to treat tuberculosis, may deplete levels of niacin and cause a deficiency.

    Nicotine Patches
    The use of nicotine patches with niacin may worsen or increase the risk of flushing reactions associated with this vitamin when used medicinally.


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    Supporting Research

    Adding vitamins to the mix: skin care products that can benefit the skin [press release]. American Academy of Dermatology; March 11, 2000.

    Antoon AY, Donovan DK. Burn Injuries. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. Philadelphia, Pa: W.B. Saunders Company; 2000:287-294.

    Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Safety. 1998;19(5):355-371.

    Brown BG, Zhao XQ, Chalt A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345(22):1583-1592.

    Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol. Dec 17, 1998;82:74U81U.

    Cumming RG, Mitchell P, Smith W. Diet and cataract: the Blue Mountains Eye Study. Ophthalmology. 2000;107(3):450-456.

    De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr. 1998;128:797-803.

    Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet Z. Pharmacokinetics of nicotinic acid-salicylic acid interaction. Clin Pharmacol Ther. 1989;46(6):642-647.

    Elam M, Hunninghake DB, Davis KB, et al. Effects of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial. JAMA. 2000;284:1263-1270.

    Gaby AR. Natural treatments for osteoarthritis. Altern Med Rev. 1999;4(5):330-341.

    Gardner SF, Marx MA, White LM, et al. Combination of low-dose niacin and pravastatin improves the lipid profile in diabetic patients without compromising glycemic control. Ann Pharmacother. 1997;31(6):677-682.

    Gardner SF, Schneider EF, Granberry MC, Carter IR. Combination therapy with low-dose lovastatin and niacin is as effective as higher-dose lovastatin. Pharmacother. 1996;16:419423.

    Garg A. Lipid-lowering therapy and macrovascular disease in diabetes mellitus. Diabetes. 1992;41(Suppl 2):111-115.

    Goldberg A, Alagona P, Capuzzi DM, et al. Multiple-dose efficacy and safety of an extended-release form of niacin in management of hyperlipidemia. Am J Cardiol. 2000;85:1100-1105.

    Guyton JR. Effect of niacin on atherosclerotic cardiovascular disease. Am J Cardiol. Dec 17, 1998;82:18U23U.

    Guyton JR, Capuzzi DM. Treatment of hyperlipidemia with combined niacin-statin regimens. Am J Cardiol. Dec 17, 1998;82:82U84U.

    Jacques PF, Chylack LT Jr, Hankinson SE, et al. Long-term nutrient intake and early age related nuclear lens opacities. Arch Ophthalmol. 2001;119(7):1009-1019.

    Jokubaitis LA. Fluvastatin in combination with other lipid-lowering agents. Br J ClinPract. 1996;77A(Suppl):28-32.

    Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: A pilot study. Inflamm Res. 1996;45:330-334.

    Kirschmann GJ, Kirschmann JD. Nutrition Almanac. 4th ed. New York: McGraw-Hill;1996:88-99.

    Kuroki F, Iida M, Tominaga M, et al. Multiple vitamin status in Crohn's disease. Dig Dis Sci. 1993;38(9):1614-1618.

    Kuzniarz M, Mitchell P, Cumming RG, Flood VM. Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2001;132(1):19-26.

    Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-440.

    McCarty MF. Niacinamide therapy for osteoarthritis does it inhibit nitric oxide synthase induction by interleukin-1 in chondrocytes? Med Hypotheses. 1999;53(4):350-360.

    Meyer NA, Muller MJ, Herndon DN. Nutrient support of the healing wound. New Horizons. 1994;2(2):202-214.

    Nutrients and Nutritional Agents. In: Kastrup EK, Hines Burnham T, Short RM, et al, eds. Drug Facts and Comparisons. St. Louis, Mo: Facts and Comparisons; 2000:4-5.

    O'Hara J, Nicol CG. The therapeutic efficacy of inositol nicotinate (Hexopal) in intermittent claudication: a controlled trial. Br J Clin Prac. 1988;42(9):377-381.

    Omray A. Evaluation of pharmacokinetic parameters of tetracylcine hydrochloride upon oral administration with vitamin C and vitamin B complex. Hindustan Antibiot Bull. 1981;23(VI):33-37.

    Physicians' Desk Reference. 54th ed. Montvale, NJ: Medical Economics Co., Inc.: 2000:1519-1523.

    Rockwell KA. Potential interaction between niacin and transdermal nicotine. Ann Pharmacother. 1993;27(10):1283-1288.

    Torkos S. Drug-nutrient interactions: a focus on cholesterol-lowering agents. Int J Integrative Med. 2000;2(3):9-13.

    Visalli N, Cavallo MG, Signore A, et al. A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI). Diabetes Metab Res Rev. 1999;15(3):181-185.

    Whelan AM, Price SO, Fowler SF, et al. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract. 1992;34(2):165-168.

    Yee HS, Fong NT, Atorvastatin in the treatment of primary hypercholesterolemia and mixed dyslipidemias. Ann Pharmacother. 1998 Oct;32(10):1030-1043.


    --------------------------------------------------------------------------------

    Review Date: April 2002
    Reviewed By: Participants in the review process include: Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley Hospital, Harvard University and Senior Medical Editor Integrative Medicine, Boston, MA; Gary Kracoff, RPh (Pediatric Dosing section February 2001), Johnson Drugs, Natick, Ma; Steven Ottariono, RPh (Pediatric Dosing section February 2001), Veteran's Administrative Hospital, Londonderry, NH; Margie Ullmann-Weil, MS, RD, specializing in combination of complementary and traditional nutritional therapy, Boston, MA. All interaction sections have also been reviewed by a team of experts including Joseph Lamb, MD (July 2000), The Integrative Medicine Works, Alexandria, VA;Enrico Liva, ND, RPh (August 2000), Vital Nutrients, Middletown, CT; Brian T Sanderoff, PD, BS in Pharmacy (March 2000), Clinical Assistant Professor, University of Maryland School of Pharmacy; President, Your Prescription for Health, Owings Mills, MD; Ira Zunin, MD, MPH, MBA (July 2000), President and Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu, HI.


    Copyright 2004 A.D.A.M., Inc

  11. #11
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    awesome post easto

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    A Legend bleachcola's Avatar
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    Cool story Hansel.

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    PR Hungry Winter's Avatar
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    Quote Originally Posted by bleachcola
    Lowers LDL and raises HDL. Won't be able to get enough from food to see a difference, have to supplement for that effect.
    Do you mean lowers HDL and raises LDL?

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    A Legend GymLift's Avatar
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    Quote Originally Posted by Easto
    However. High doses of niacin produce the side effects of flushing of the skin (which can be reduced by taking aspirin 30 minutes before the niacin), stomach upset (which usually subsides in a few weeks), headache, dizziness, blurred vision, and liver damage. Although the time-release form of niacin reduces flushing, long-term use is associated with liver damage.
    Ouch. That isn't cool.

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    Quote Originally Posted by Winter
    Do you mean lowers HDL and raises LDL?
    No.

    Remember, HDL=Good, LDL=Bad.

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    Eze
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    Everything is bad for your liver... haven't you learned that yet?

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    A Legend bleachcola's Avatar
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    Quote Originally Posted by Winter
    Do you mean lowers HDL and raises LDL?
    Nope, high density single bonds are where it's at.

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