Anabolic steroids, bodybuilding discussion forums. - Steroidology

rui products
 

This Forum Supports knowledge and information on the safe use of legal alternatives to synthetic steroids including but no limited to Pro hormones , and natural steroids.

Results 1 to 19 of 19
  1. #1
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    So you want to try Ostarine (MK2866)... HERE ARE THE FACTS OF THIS WONDERFUL SARM
    What is Ostarine?

    Ostarine is the SARM that GTx is developing for the prevention and treatment of muscle wasting. It is currently undergoing clinical trials and may eventually be the medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy.

    As a research chemical, Ostarine belongs to a class of chemicals known as SARMs or selective androgen receptor modulators. sarms create selective anabolic activity at certain androgen receptors and not others, hence their name. Compared to testosterone and other anabolic steroids and pro hormones, the advantage of sarms such as (Ostarine) MK-2688 is that they do not have androgenic activity in non-skeletal-muscle tissues.
    Ostarine is effective in not only maintaining lean body mass (LBM) but actually increasing it.

    It is often described or named S1 on various interenet sources, however this is actually incorrect as S1 was a SARM that was develped quite early and is no longer undergoing any further development.

    How does it work?


    Selective androgen receptor modulators (SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
    Androgen receptor activation

    Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis, hence builds muscle.
    So in essence, sarms such as Ostarine causes muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids and prohormones, sarms (as nonsteroidal agents) don***8217;t produce the growth effect on prostate and other secondary sexual organs.

    Ostarine in particular exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for Bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.



    Evidence of Ostarine***8217;s Abilities?


    To date, GTx has evaluated Ostarine in eight clinical trials involving approximately 600 subjects including three efficacy studies. A four month Phase IIb clinical trial enrolled 159 patients with the study meeting its primary objective of an absolute increase in total lean body mass (muscle) compared to placebo and the secondary objective of muscle function (increase in strength).

    In particular application to bodybuilding, there have been many logs of users on various forums using Ostarine as an aid to increase lean body mass and strength levels.




    Uses of Ostarine

    Lean muscle gains (bulking)




    As Ostarine is the most anabolic of the available sarms, its first and formost use must be when trying to gain lean muscle.
    Now the gains in absolute weight won***8217;t be comparable to steroids such as diannabol, however what will be gained will almost exclusivley be lean mass. Due to the lack of shutdown in comparison to steroids/prohormones, a PCT period is not needed and almost all the mass that is gained on Ostarine is kept once the cycle is finished.
    Doses of 25mg for 4-6 weeks are the most common protocol for such goals. Over this 4-6 week period will typically produce 6lbs or 3kg of lean, keepable gains. However the abundant side effects of steroids/Prohormones will not be present.

    Users have as high as 36mg [only recommended for those who weigh in at 210lbs (95kg)+] for periods as long as 8 weeks. However the potential for suppression from such doses is higher and users would have to look into a PCT protocol after undergoing such a cycle.
    As the majority of Ostarine supplies come in 30ml bottles at 25mg/ml, a dose of 17.5mg per day will give the user a 6 week cycle from one bottle, a very good compromise between an anabolic dose and cost.

    Losing Bodyfat (cutting)



    Ostarine would primarily fit into a cutting protocol for the maintainance of muscle mass whilst reducing calories.
    One of the most disheartening outcomes of cutting is the loss hard earned muscle mass.
    The drop in ********* rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic enviroment for loss of muscle tissue.
    As Ostarine has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss.
    Ostarine has also shown noticeable nutrient partioining effects among users, another reason why it can be of great help when cutting.

    A 12.5-15mg dosing protocol for 4-6 weeks is good for cutting with Ostarine without undergoing any side effects or suppression.
    However it must be stated that due to the lack of androgenicity, muscle hardness and overall results are not as prominenant as with the SARM S-4.

    Recomping (gaining muscle and losing bodyfat at the same time)
    Recomping is where Ostarine really shines.
    The recomping effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult.
    Where Ostarine shines for recomping is in its nutrient partioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that Ostarine consumed at maintainace calories produces weight loss, whilst still getting increases in strength and muscle mass!

    One of the most important factors of recomping is TIME. As you are trying to achieve multiple objectives, it requires a longer time period to notice good recomp effects so even when running steroids, these would have to be longer run injectible compounds as oppose to the short used Liver toxic oral steroids/Prohormones.

    Although Ostarine is taken orally, as it is not methylated it is not as Liver toxic as other oral steroids/Prohormones. Therefore it can be run for longer than the standard 4 week period with the aforementioned compounds.

    The dosing protocol of 12.5-25mg for 4-8 weeks will give excellent recomp effects.
    Diet must also be optimized to where calories are just above maintaninance with at least 30% coming from lean sources of protein to get the best recomp effect.

    Injury Prevention



    As mentioned by Furuya, the effects of MK-2688 translate to anabolism in bone as well as skeletal muscle tissue, which means it could be used in the future for a wide variety of uses such as osteoporosis and as a concurrent treatment with drugs that reduce bone density.
    Therefore it has great application as a compound to use for rehabilitation of injuries, in particular bone and tendon related injuries.

    Doses of 12.5mg per day is recommend for such purposes and improvement in Joint movement that can be seen after just 6-8 days.


    Timing of Doses

    As Ostarine has a half life of around 24 hours, each of these doeses only has to be taken orally once a day, therefore its also offers an extremely convientinet supplementation intake.
    Ostarine and estrogen concern

    sarms cannot be aromatized, conferring all their effects to AR binding and not to ********* conversion to active androgens/estrogens.
    However blood work from users has shown a slight elevation in serum estradiol levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses.
    This elevation is extremely small and is no case for concern. If however you are absolutely concerned about slight increases in Estrogen, you can always opt for low doses of OTC AI***8217;s such as 6bromo or very very low doses of prescription AI***8217;s like adex or aromasin.

    Advantages Of Ostarine when compared to Steroids/Prohormones

    There is no need for pre cycle supports such as Hawthorn berry.

    There is no need for on cycle supports such as milk thistle for the Liver, policosanol or RYR for cholesterol etc.

    Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent PCT of prescription SERMs like nolva or Clomid is not necessary.

    High oral biovailabilty without significant damage to your Liver as with oral steroids/Prohormones.

    Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lifes).

    No need for a long time period off between cycles; the recommended time of period for normal cycles would be Time on +PCT, so for a typical 6 week cycle and 4 week post cycle therapy (pct), a user would have to wait another 10 weeks after PCT to start another cycle.

    Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category ***8211; hence there is little impact on cholesterol values.


    Advantages Of Ostarine when compared to other sarms


    The metabolite M1 wich seems to cause toxicity in S4 (temporary occular disturbances) is not present in Ostarine.

    Also unlike S4, Ostarine does not have androgenic properties in non muscle tissue.


    Ostarine Summary


    Anabolic even at doses as low as 3mg

    Great for strength

    Great for lean mass gains

    Great for body recomposition

    Great for endurance (aerobic or anaerobic)

    Joint healing abilities

    Half life of circa 24 hours ***8211; only once a day dosing required
    Last edited by dylangemelli; 03-16-2012 at 01:50 PM.

  2. #2
    MR SUPPS Company Rep mich29's Avatar
    Join Date
    Sep 2010
    Posts
    1,733
    Rep Power
    4
    bumping for a great write up.

    I hear Uniquemicals has a nice selection of sarms productions and more .

  3. #3
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    Quote Originally Posted by mich29 View Post
    bumping for a great write up.

    I hear Uniquemicals has a nice selection of sarms productions and more .

    thanks bro... i appreciate it... and you heard right about uniquemicals... absolutely awesome...

    btw... I don't know how I ever didn't notice this, but i love your avatar!

  4. #4
    Pro Bodybuilder
    Join Date
    Dec 2011
    Location
    Shytown....
    Posts
    2,201
    Rep Power
    3
    good article.

  5. #5
    Pro Bodybuilder BigKevKris's Avatar
    Join Date
    Jan 2011
    Location
    USA
    Posts
    1,264
    Rep Power
    4
    Excellent write up Dylan....great info. Looking forward to my MK / s4 stack during PCT for my test run....already ordered from Uniquemicals...cant beat that price

  6. #6
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    thanks guys... kev, you are in for one hell of a ride my friend... i know you will love it!

  7. #7
    Novice bcopp's Avatar
    Join Date
    Dec 2011
    Posts
    130
    Rep Power
    3
    Good post. Just to let everyone know, I took ostarine during a cut. I cut from 220 lbs to 200 lbs in about 2 months fairly easily, cardio 4-5 times a week, 500 calorie deficit (12.5 mg a day, if i try it again i may bump it up to 25mg a day). I kept my muscle mass and actually got stronger while dropping fat. I may use it again for bridging/pct in my up coming AAS cycle.

  8. #8
    Novice
    Join Date
    Feb 2012
    Posts
    64
    Rep Power
    3
    Nice post!

  9. #9
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    it is very versatile... i used it in my post cycle therapy (pct) and then ran it right after stacked with s4 and have yielded fcking awesome results on it... check out my log and see... my strength is through the roof and i have added 5 pounds of lean muscle since the end of my helladrol cycle and my body fat has gone down...

  10. #10
    lab rat
    Join Date
    Mar 2012
    Location
    vegas baby!
    Posts
    5
    Rep Power
    0
    i tried the mt II from gwp and i am darker after 4 days than at the end of the year so i am trusting their mk-2866.

  11. #11
    Novice olivierf57's Avatar
    Join Date
    Jun 2011
    Posts
    57
    Rep Power
    4
    Absolutely no results with UD2 protocol for cutting ! It's even the contrary.
    I usually loose between 3 and 4 lbs/week with UD2 but with Osta, I just lost 1 or 2lbs/week since 4 weeks ! Strange.

    Moreover, no increase of strength !

    My dosage is 15mg/day and it's my 3rd week (see my log in this forum).

    Disappointed....

  12. #12
    Rookie
    Join Date
    Mar 2012
    Posts
    5
    Rep Power
    0
    Great post!!

  13. #13
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    Quote Originally Posted by olivierf57 View Post
    Absolutely no results with UD2 protocol for cutting ! It's even the contrary.
    I usually loose between 3 and 4 lbs/week with UD2 but with Osta, I just lost 1 or 2lbs/week since 4 weeks ! Strange.

    Moreover, no increase of strength !

    My dosage is 15mg/day and it's my 3rd week (see my log in this forum).

    Disappointed....

    have you seen my osta and s4 log?? first of all, osta is not a big cutter, s4 is the one that will be more of a cutter... your not supposed to dro pa bunch of weight on osta... you can up your dosing to 25 mg to get the most out of it as well... as far as your strength, you should see an increase but you will get much more benefit by running s4 and osta together... plus, it depends on where you bought it from and how strong it is... these are all factors to consider with it...

  14. #14
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    Quote Originally Posted by akolatier View Post
    Great post!!
    thanks bro!!

  15. #15
    Pro Bodybuilder
    Join Date
    Dec 2011
    Location
    Shytown....
    Posts
    2,201
    Rep Power
    3
    Quote Originally Posted by olivierf57 View Post
    Absolutely no results with UD2 protocol for cutting ! It's even the contrary.
    I usually loose between 3 and 4 lbs/week with UD2 but with Osta, I just lost 1 or 2lbs/week since 4 weeks ! Strange.

    Moreover, no increase of strength !

    My dosage is 15mg/day and it's my 3rd week (see my log in this forum).

    Disappointed....
    you are one of few who its doesnt work for, or just get less results. sry bro

  16. #16
    Novice olivierf57's Avatar
    Join Date
    Jun 2011
    Posts
    57
    Rep Power
    4
    I will give Osta the time....

    and I will come back here in few weeks to give my opinion.

  17. #17
    Rookie
    Join Date
    Mar 2012
    Posts
    1
    Rep Power
    0
    Is (1) bottle of Osta sufficient for a 4-6 week cycle @ 25mg dosage?

  18. #18
    Amateur Bodybuilder dylangemelli's Avatar
    Join Date
    Dec 2011
    Location
    MAUI
    Posts
    820
    Rep Power
    3
    Quote Originally Posted by Rabid Dawg View Post
    Is (1) bottle of Osta sufficient for a 4-6 week cycle @ 25mg dosage?
    1 bottle from uniquemicals.com at 25 mg a day should last you 60 days... its a 50ml bottle at 50 mg / ml...

  19. #19
    Rookie
    Join Date
    Mar 2012
    Posts
    7
    Rep Power
    0
    Ostarine timing+Mk-677
    Hi,

    I am starting a stack of osta and MK-677. Would it be better to take the Mk-677 on an empty stomach or at least to avoid carbs with it as it should release hgh?

    And ostarine with food or together with the mk on an empty stomach before my morning workout?
    and can i throw in a workout booster like jack3d or does this affect the serms?

    thanks

    fitstar

uniquemicals
Thread Information
Users Browsing this Thread

There are currently 3 users browsing this thread. (0 members and 3 guests)

Similar Threads
  1. By MikeKen in forum Chemical Study
    Replies: 3
    Last Post: 11-05-2013, 02:16 PM
  2. By dylangemelli in forum Pro Hormone - Natural Steroids and Steroid Alternatives
    Replies: 28
    Last Post: 07-16-2012, 11:31 PM
  3. By juced_porkchop in forum Anabolic Steroids and Bodybuilding Articles
    Replies: 0
    Last Post: 11-04-2011, 04:11 PM
  4. By TickleMyPeon in forum Anabolic Steroid Forum
    Replies: 19
    Last Post: 06-01-2011, 09:22 PM
  5. Replies: 22
    Last Post: 02-03-2010, 06:54 PM
Tags for this Thread
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
  

3Js Nutrition Network

juicepump







solid muscle isolate 5lb





3Js Nutrition Network

solid muscle isolate 5lb