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  1. #1
    Junior Bodybuilder Milas's Avatar
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    Uniquemicals GW1516 - Exercise in a Bottle?
    I heard Uniquemicals was getting GW1516 on their site soon. Anyone tried this yet?




    From Wiki:
    GW-501516 (also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

    GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

    It has been demonstrated at oral doses of 5 mg a day to reverse ********* abnormalities in obese men with pre-diabetic ********* syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

    Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.

  2. #2
    MR SUPPS Company Rep mich29's Avatar
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    bumping a solid thread with some good info on it

  3. #3
    Amateur Bodybuilder Colbert's Avatar
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    I've seen nothing but good reports on it and basskilleronline says the same thing about it.

  4. #4
    Novice fasttimes's Avatar
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    Cool
    guys my lab rat has been on 1 ml a day for the last 2 weeks and has nothing to report. If my rat was transformed into a man he'd be 5'8 around 190 lbs about 12% bf and 46years old, he would be on the weights 3 to 5 times a week, with very little cardio. My rat spelled out " not impressed" in his litter box.

  5. #5
    Amateur Bodybuilder Colbert's Avatar
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    Quote Originally Posted by fasttimes View Post
    guys my lab rat has been on 1 ml a day for the last 2 weeks and has nothing to report. If my rat was transformed into a man he'd be 5'8 around 190 lbs about 12% bf and 46years old, he would be on the weights 3 to 5 times a week, with very little cardio. My rat spelled out " not impressed" in his litter box.
    how was your rats diet?

  6. #6
    Amateur Bodybuilder Osta-Marketing's Avatar
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  7. #7
    Novice fasttimes's Avatar
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    my rats diet was unchanged over the two weeks, his diet wasnt deficient to bias testing one way or another. My rat has tested both of unique's other products and observed results. I'm going to make him do some cardio over the next two weeks left in this bottle and see if his apperance changes.

  8. #8
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    really intrested to see the results..

    Osta Gain are they for human consumption? If not, what is the reason?

  9. #9
    Junior Bodybuilder Logical's Avatar
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    Quote Originally Posted by Bugmenot View Post
    really intrested to see the results..

    Osta Gain are they for human consumption? If not, what is the reason?
    "research purposes"

  10. #10
    MR SUPPS Company Rep mich29's Avatar
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    Quote Originally Posted by fasttimes View Post
    my rats diet was unchanged over the two weeks, his diet wasnt deficient to bias testing one way or another. My rat has tested both of unique's other products and observed results. I'm going to make him do some cardio over the next two weeks left in this bottle and see if his apperance changes.
    sounds good.very interested in your results

  11. #11
    Rookie Minister's Avatar
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    Quote Originally Posted by fasttimes View Post
    guys my lab rat has been on 1 ml a day for the last 2 weeks and has nothing to report. If my rat was transformed into a man he'd be 5'8 around 190 lbs about 12% bf and 46years old, he would be on the weights 3 to 5 times a week, with very little cardio. My rat spelled out " not impressed" in his litter box.
    My subject researched GW some time ago, my friend got a hold of some from a research company and it was a good product ,at 5 mgs a day subject had some decent BF management, but then the source dried up , got some from another place and it was junk, so we gave up, but now Osta-gain has it in stock so I got some on the way , can't wait to try it, I have used osta-gain for a year now and never had a quality issue from them. I will do my GW ,osta-max combo and see how it goes. God bless you brothers. Minister.

  12. #12
    Amateur Bodybuilder Colbert's Avatar
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    I'm so confused about GW. Some people have amazing results and some people don't. There has to be something that is making it work for some people and some people not.

  13. #13
    Rookie Minister's Avatar
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    Quote Originally Posted by Colbert View Post
    I'm so confused about GW. Some people have amazing results and some people don't. There has to be something that is making it work for some people and some people not.
    How are you bro? Well, I believe it has to do with the quality of the product. When research was done by our subjects some time ago, there was one product that was effective and then we got some from different place and got nothing out of it. I got mine yesterday, so research will start tomorrow. Will update. God bless you. Minister.

  14. #14
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    Looking forward to the updates Minister!

    What will your dosages look like?

    If all goes well, i too will order some !

    Thanks brother

  15. #15
    MR SUPPS Company Rep mich29's Avatar
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    from what I've seen so far this stuff is the real deal.the uniquemicals brand got some great reviews on it..

    def interested in more reviews though

  16. #16
    Novice fasttimes's Avatar
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    Quote Originally Posted by mich29 View Post
    from what I've seen so far this stuff is the real deal.the uniquemicals brand got some great reviews on it..

    def interested in more reviews though
    hey brother could you paste some links to the favorable reviews , I 'd like to compare my research. thanks

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