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This forum is dedicated to the Science of protein peptides.

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  1. #1
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    Default TB500 -- Learn how it works!
    So recently there has been a lot of talk about this peptide. Statement like, “It will help you heal faster”. “You recover more quickly from injuries” and so on. So what is TB500, what does it do, and how does it work.

    TB 500 is a naturally occurring peptide. It is part of the thymosin family of peptides. Structurally it is unique in that it has a unique binding ability. This is relative in that it binds to certain substances and transports them to areas of injury. TB500 is found throughout the body, in many tissues, but is heavily concentrated in areas of injury.

    The first effect of Tb 500 is it reduces inflammation. It does this via 2 mechanisms. It first works to lower inflammatory inducing cytokines. These cytokines induce systemic inflammation. Secondly there is a derivative of TB 500 that actually works to reduce inflammation of white blood cells. The cells responsible for immune system function.

    As far as healing there are 2 primary mechanisms that TB 500 utilizes to promote and expedite healing. First it has a direct effect on Actin. Actin is a hair like substance that surrounds cells. It is responsible for the movement, growth and binding of cells. It plays a crucial role in healing. Second it is responsible for the activation of cells known as progenitor cells. These cells are unique in that they can assimilate with different cell types. They also produce protein and growth factors that promote healing.

    As you can see TB500 isn’t just some peptide that worked in horses so it will work in our research, it has hard data supporting its effects and the benefits of those effects are often desired in our researching. The goal of this write up was to point those benefits out and support them with solid references.

    Get it here >> TB 500 2mg


    Refs:
    *Philp D, Kleinman HK (April 2010). "Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide". Ann. N. Y. Acad. Sci. 1194: 81–6. doi:10.1111/j.1749-6632.2010.05479.x. PMID 20536453
    *Riley PR, Smart N (December 2009). "Thymosin beta4 induces epicardium-derived neovascularization in the adult heart". Biochem. Soc. Trans. 37 (Pt 6): 1218–20. doi:10.1042/BST0371218. PMID 19909250
    *oung JD, Lawrence AJ, MacLean AG, et al. (December 1999). "Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids". Nat. Med. 5 (12): 1424–7. doi:10.1038/71002. PMID 10581087
    *Thymosin ***946;4 Is Cardioprotective after Myocardial Infarction DEEPAK SRIVASTAVA1, ANKUR SAXENA2, J. MICHAEL DIMAIO3, ILDIKO BOCK-MARQUETTE3 Article first published online: 10 OCT 2007DOI: 10.1196/annals.1415.04
    *The ***946;-thymosins: Intracellular and extracellular activities of a versatile actin binding protein family Hans Georg Mannherz1,2,*, Ewald Hannappel3Ar ticle first published online: 29 APR 2009DOI: 10.1002/cm.20371
    Bigasian likes this.

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  2. #2
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    Study it......

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    Great read and great product!

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  4. #4
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    This one is growing. Thank you for the support guys!

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  5. #5
    Moderator JimiThing's Avatar
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    Good write up...explains al lot of the effects im getting and reporting in my log.

  6. #6
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    Should I store my unmixed TB-500 in the freezer? I bought 12 2mg vials for a 6 week research period.

  7. #7
    Amateur Bodybuilder tballz's Avatar
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    Quote Originally Posted by wodkiller View Post
    Should I store my unmixed TB-500 in the freezer? I bought 12 2mg vials for a 6 week research period.
    Yes, put unmixed vials in the freezer.

  8. #8
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    Quote Originally Posted by tballz View Post
    Yes, put unmixed vials in the freezer.
    Thank you!

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    TB-500 is the real deal - when added to HGH (every week, post trauma) injections it makes quick work of many recoveries

  10. #10
    Junior Bodybuilder kfairhurst's Avatar
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    I'm looking forward for my TB-500 to kick in, started last Friday and and loading at 5mg per week. Nothing to report just yet, but it should kick in in a few weeks.

  11. #11
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    What people are saying about tb500 What Researchers are Saying About TB500 :

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  12. #12
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    Bump....

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  13. #13
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    Excellent product to research with >> TB 500 2mg

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    RUI, jimi, tballz....

    I just finished a loading phase of 4mg a week for 6 weeks. What now? 5mg a month? One injection of 5mg or 2.5 first of the month and 2.5 last of the month? Looking for some information on this from people who have experience using it.

    THANK YOU

  15. #15
    Moderator JimiThing's Avatar
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    Quote Originally Posted by wodkiller View Post
    RUI, jimi, tballz....

    I just finished a loading phase of 4mg a week for 6 weeks. What now? 5mg a month? One injection of 5mg or 2.5 first of the month and 2.5 last of the month? Looking for some information on this from people who have experience using it.

    THANK YOU
    http://www.steroidology.com/forum/pe...ml#post3178449
    My maintenance protocol....

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    Quote Originally Posted by tballz View Post
    Yes, put unmixed vials in the freezer.
    Once reconstituted, can it also be put in the freezer in order to preserve it past 8 days? I have a 10mg vial for which the first and last dose would be 14 days apart, it is my understanding that once reconstituted TB500 is only good for about 8 days.

  17. #17
    Amateur Bodybuilder tballz's Avatar
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    Quote Originally Posted by jabrel3 View Post
    Once reconstituted, can it also be put in the freezer in order to preserve it past 8 days? I have a 10mg vial for which the first and last dose would be 14 days apart, it is my understanding that once reconstituted TB500 is only good for about 8 days.
    For peptides, I reconstitute, then pre-load pins, and freeze them.

  18. #18
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    Quote Originally Posted by jabrel3 View Post
    Once reconstituted, can it also be put in the freezer in order to preserve it past 8 days? I have a 10mg vial for which the first and last dose would be 14 days apart, it is my understanding that once reconstituted TB500 is only good for about 8 days.
    I personally don't like freezing peptides once mixed and I feel the water expanding when freezing and shrinking when melting may damage pep, but I know a lot of guys that do this with many peptides and they still work fine. so you can do this if its easyer for you.
    I just keep mine in fridge once mixed and use up within 4 weeks. I really don't think 2 weeks would be much of an issue with TB500.

    if your worried about it sitting too long, fill and freeze like posted above and your GTG.

  19. #19
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    Start your research here >> TB 500 2mg

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  20. #20
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    Quote Originally Posted by juced_porkchop View Post
    I personally don't like freezing peptides once mixed and I feel the water expanding when freezing and shrinking when melting may damage pep, but I know a lot of guys that do this with many peptides and they still work fine. so you can do this if its easyer for you.
    I just keep mine in fridge once mixed and use up within 4 weeks. I really don't think 2 weeks would be much of an issue with TB500.

    if your worried about it sitting too long, fill and freeze like posted above and your GTG.
    I think OP was referring to UNMIXED, but I still agree with you. Un reconstituted TB is fairly stable, and really just needs a dark, cool, dry place, like a medicine cabinet or sock drawer, imho.

    Quote Originally Posted by 956Vette View Post
    TB-500 is the real deal - when added to HGH (every week, post trauma) injections it makes quick work of many recoveries
    Good to see you Vette! I've been "preaching" TB since you first suggested it to me. however, TB is fairly effective, and inexpensive. Really don't think it is necessary to add the GH, unless a major injury.

    BTW... thanks for point it out to me several months ago. I think I will always keep a small quantity on hand "just in case".

    ---Roman

  21. #21
    Novice mr.bean's Avatar
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    This one is new to me, saw the name a few times but it sure looks nice.
    you think this could be used for say 6 months without issues?

    how long are people using this peptide?

    Thanks guys

  22. #22
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    Quote Originally Posted by RUI-products View Post
    The following are a few short excerpts of what researchers all over have observed in their research administering the exciting new peptide TB 500 to research subjects:


    "this definitely has a profound effect on inflammation and pain."

    "observed a greater range of motion and less discomfort than I have in a very long time."

    "the only thing I can say for sure is it definitely helped with my research subjects injuries and I would use it on them again for sure"

    "In looking at how far my research subjects injury has come and how quickly , to think the TB500 didn't play a role in that would be foolish"

    "healing is noticeable and without question."

    "..does seem to have a noticeable effect."


    As you can see above TB500 is a compound definitely worth looking into for your research purpose. To read more about it click here >> TB500 - 2mg
    What people are saying ^^

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  23. #23
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    Quote Originally Posted by mr.bean View Post
    This one is new to me, saw the name a few times but it sure looks nice.
    you think this could be used for say 6 months without issues?

    how long are people using this peptide?

    Thanks guys
    It seems like people use a build up dose of 3-5mg ew for a few weeks then run 1-2mg ew after that for anywhere from 2-4+ months.
    Its use has exploded with good feedback but you probibly wont find a "set in stone" way to use it.
    I would rec (from my research) the following:

    wk1-4 3-4mg ew (1.5-2mg 2X a week 3-4 days apart)
    wk4-16 1-2mg ew (In one shot seems the norm, but you could do two)

    if your blood work is not wack then i guess you could run it a bit longer but I myself will be doing my research with it at 3-6month cycles of use
    at a time.
    All seems very promising but I would not just run it year round non stop... at least no yet.
    I myself am interested in this peptide.
    I have some medical issues I hope this may help with and have LOVED IGF'1s effects over the last couple years.


    Hope that helps a bit.

  24. #24
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    Quote Originally Posted by RUI-products View Post
    So recently there has been a lot of talk about this peptide. Statement like, ***8220;It will help you heal faster***8221;. ***8220;You recover more quickly from injuries***8221; and so on. So what is TB500, what does it do, and how does it work.

    TB 500 is a naturally occurring peptide. It is part of the thymosin family of peptides. Structurally it is unique in that it has a unique binding ability. This is relative in that it binds to certain substances and transports them to areas of injury. TB500 is found throughout the body, in many tissues, but is heavily concentrated in areas of injury.

    The first effect of Tb 500 is it reduces inflammation. It does this via 2 mechanisms. It first works to lower inflammatory inducing cytokines. These cytokines induce systemic inflammation. Secondly there is a derivative of TB 500 that actually works to reduce inflammation of white blood cells. The cells responsible for immune system function.

    As far as healing there are 2 primary mechanisms that TB 500 utilizes to promote and expedite healing. First it has a direct effect on Actin. Actin is a hair like substance that surrounds cells. It is responsible for the movement, growth and binding of cells. It plays a crucial role in healing. Second it is responsible for the activation of cells known as progenitor cells. These cells are unique in that they can assimilate with different cell types. They also produce protein and growth factors that promote healing.

    As you can see TB500 isn***8217;t just some peptide that worked in horses so it will work in our research, it has hard data supporting its effects and the benefits of those effects are often desired in our researching. The goal of this write up was to point those benefits out and support them with solid references.

    Get it here >> TB 500 2mg


    Refs:
    *Philp D, Kleinman HK (April 2010). "Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide". Ann. N. Y. Acad. Sci. 1194: 81***8211;6. doi:10.1111/j.1749-6632.2010.05479.x. PMID 20536453
    *Riley PR, Smart N (December 2009). "Thymosin beta4 induces epicardium-derived neovascularization in the adult heart". Biochem. Soc. Trans. 37 (Pt 6): 1218***8211;20. doi:10.1042/BST0371218. PMID 19909250
    *oung JD, Lawrence AJ, MacLean AG, et al. (December 1999). "Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids". Nat. Med. 5 (12): 1424***8211;7. doi:10.1038/71002. PMID 10581087
    *Thymosin ***946;4 Is Cardioprotective after Myocardial Infarction DEEPAK SRIVASTAVA1, ANKUR SAXENA2, J. MICHAEL DIMAIO3, ILDIKO BOCK-MARQUETTE3 Article first published online: 10 OCT 2007DOI: 10.1196/annals.1415.04
    *The ***946;-thymosins: Intracellular and extracellular activities of a versatile actin binding protein family Hans Georg Mannherz1,2,*, Ewald Hannappel3Ar ticle first published online: 29 APR 2009DOI: 10.1002/cm.20371
    Quality product ^^

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    Follow us on twitter @ruiproducts for promotions, sales, and articles.
    Last edited by RUI-products; 04-03-2014 at 12:03 PM.

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