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  1. #1
    Senior Member roccodart440's Avatar
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    Default Bovine colostrum
    chiro gave me some today and told me to add it to my post cycle therapy (pct).

    What's your take on that? Any one use the stuff?

  2. #2
    Olympian Bodybuilder DocJ's Avatar
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    As in a D.C.? I'm pretty sure colostrum is destroyed as soon as it hits your stomach acid.

  3. #3
    Senior Member roccodart440's Avatar
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    Perhaps the IGF-1 is destroyed but colostrum is said to improve immune function and some other great properties. It seems it can't all be bogus. It helps calfes survive.


    Here is some info I found

    TRADE NAMES
    Mega Bovine Colostrum (Bricker Labs)

    DESCRIPTION
    Colostrum is the pre-milk fluid produced from the mother's mammary glands during the first few days after birth. Bovine colostrum is derived from cows. Colostrum is a rich source of antibodies, growth factors and nutrients for the suckling neonate and may provide passive immunity to the newborn against various infectious microorganisms, particularly those that affect the gastrointestinal tract. It may also have other health benefits.

    The protein content of bovine colostrum is three to four times higher—up to 150 grams per liter compared to 30 to 40 grams per liter—than it is in regular cow's milk.

    The greater part of this protein is comprised of whey proteins (see Whey Proteins). Immunoglobulins, mainly IgG, make up about 75% of the whey proteins. Other substances found in bovine colostrum include casein, lactoferrin, alpha-lactalbumin, beta-lactoglobulin, and the growth factors insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGFbeta) and epidermal growth factor (EGF). In addition, bovine colostrum contains vitamins, minerals, lipids and lactose. Bovine colostrum may also contain colostrinin, also known as proline-rich polypeptide (PRP), a substance found in ovine (sheep) colostrum.

    Bovine colostrum is marketed in several forms. Bovine colostrum prepared by microfiltration is mainly composed of whey proteins and their associated immunoglobulins and the growth factors IGF-1, IGF-2, TGFbeta and EGF.

    Substances such as lactose, fats, casein and lactalbumin are significantly reduced in microfiltered bovine colostrum. Hyperimmune bovine colostrum is rich in immunoglobulins of the IgG type, which are protective against such infectious microorganisms as Cryptosporidium parvum (a major cause of AIDS-associated diarrhea), diarrheogenic Escherichia coli strains, Shigella flexneri, Clostridium difficile, and rotavirus, the most common cause of severe diarrhea in young children.

    Hyperimmune bovine colostrum is prepared from cows previously immunized with specific antigens. Hyperimmune bovine colostrum IgG concentrate is an orphan drug for the treatment of diarrhea in AIDS patients caused by infection with Cryptosporidium parvum.

    ACTIONS AND PHARMACOLOGY
    ACTIONS
    Bovine colostrum may have immunostimulatory and antimicrobial actions. It is reputed to have ergogenic activity as well.

    MECHANISM OF ACTION
    Hyperimmune bovine colostrum may have antimicrobial activity based on the ability of specific immunoglobulins of the IgG type to react with bacterial, viral and other microbiological antigens in the gut. Bovine colostrum contains a few immunostimulatory substances, including lactoferrin. It may also contain colostrinin or proline-rich polypeptide (PRP), another possible immunomodulatory substance. The combination of specific, as well as nonspecific, IgGs and such immunomodulatory factors as lactoferrin and PRP may afford general antimicrobial protection of the gastrointestinal tract.

    Bovine colostrum's putative exercise-performance-enhancment is mainly attributed to such growth factors as IGF-1.

    PHARMACOKINETICS
    The pharmacokinetics of bovine colostrum, particularly with regard to the immunoglobulins, is unclear. It would be expected that immunoglobulins found in bovine colostrum would be rapidly inactivated by stomach acid and proteolytic action in the small intestine. Enteric coating would protect the proteins from acid in the stomach but not from proteolytic activity in the small intestine. However, following ingestion of bovine colostrum, some immunoglobulins are found to be excreted intact in the feces after a few days. This suggests that some immunoglobulins may be more resistant to degradation in the gut.

    Growth factors and other peptides and proteins in bovine colostrum are most likely degraded by proteolytic enzymes and absorbed, distributed and metabolized in the same fashion as similar dietary substances.

    INDICATIONS AND USAGE
    Claims made for bovine colostrum are mostly unsubstantiated. Some preparations may have some antimicrobial effects. There is no credible evidence to support claims that bovine colostrum burns fat, builds muscle, speeds healing of injuries, regulates blood sugars, improves mood and fights depression or that it has anti-cancer effects.

    RESEARCH SUMMARY
    Well-designed, controlled clinical trials of bovine colostrum are largely lacking. A few small, usually uncontrolled or poorly controlled human studies have suggested that some components of some bovine colostrum preparations have significant antimicrobial activity. Immunoglobulins in colostrum derived from cows immunized against particular pathogens may help protect against those specific pathogens in some instances, but bovine colostrum supplements may vary widely in terms of specific constituents.

    A bovine colostrum product derived from cows immunized against Candida albicans was reported to be effective in reducing levels of this fungal pathogen in severely immunocompromised patients. Similarly, AIDS patients with chronic Cryptosporidium parvum diarrhea were said to be helped by a formulation of concentrated bovine immunoglobulins given in dosages up to 40 grams daily.

    Some bovine colostrum preparations pooled from many different cows may confer broad-spectrum antimicrobial activity, some animal research suggests. Better, designed, controlled clinical testing is needed to determine the safety and efficacy of bovine colostrum supplements.

    CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS
    CONTRAINDICATIONS
    Bovine colostrum is contraindicated in those with hypersensitivity to any component of bovine colostrum-containing products.

    PRECAUTIONS
    Pregnant women and nursing mothers should avoid bovine colostrum supplements.

    Bovine colostrum contains insulin-like growth factor-1 (IGF-1). IGF-1 levels are elevated in prostate, colorectal and lung cancer. Recent studies have found that IGF-1 levels correlate with risk of prostate cancer and colorectal cancer in men, premenopausal breast cancer in women and lung cancer in both men and women. Those with these types of cancer and those at risk for these cancers should exercise caution in the use of bovine colostrum supplements. It is unlikely that the amount of IGF-1 in bovine colostrum would be a problem, but caution should still be exercised.

    ADVERSE REACTIONS
    Adverse reactions to bovine colostrum supplements are mainly gastrointestinal and include nausea and vomiting, bloating and diarrhea. Bovine colostrum is generally well tolerated.

    DOSAGE AND ADMINISTRATION
    Bovine colostrum is available in several forms, including tablets, powders, bars and liquid solutions. Dosage is variable. Hyperimmune bovine colostrum used for AIDS-associated diarrhea usually caused by Cryptosporidium parvum is dosed at 10 grams four times daily for 21 days. This must only be taken under medical supervision.

    HOW SUPPLIED
    Powder

    Tablets — 1000 mg

    LITERATURE
    Bitzan MM, Gold BD, Philpott DJ, et al. Inhibition of Heliobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. J Infect Dis. 1998; 177:955-961.

    Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Crytosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Rretrovirol. 1996; 13:348-354.

    Huppertz HI, Rutkowski S, Busch DH, et al. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin-producing E. coli, and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr. 1999; 29:452-456.

    Lissner R, Thurmann PA, Merz G, Karch H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows (Lactobin) to healthy volunteers. Int J Clin Pharmacol Ther. 1998; 36:239-245.

    Merendino N, Prosperi S, Franci O, et al. Immunomodulatory activity of bovine colostrum on human peripheral blood mononuclear cells. J Nutr Immunol. 1996; 4:5-21.

    Mero A, Miikkulainen H, Riski J, et al. Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone and saliva IgA during training. J Appl Physiol. 1997; 83: 1144-1151.

    Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 1999; 44:653-658.

    Petschow BW, Talbott RD. Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastric acid and digestive enzymes. J Pediatr Gastroenterol Nutr. 1994; 19:228-235.

    Popik P, Bobula B, Janusz M, et al. Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats. Pharmacol Biochem Behav. 1999; 64:183-189.

    Sarker SA, Caswall TH, Mahalanabis D, et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J. 1998; 17:1149-1154.

    Tacket CO, Binion SB, Bostwick E, et al. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigellla flexneri challenge. Am J Trop Med Hyg. 1992; 47:276-283.

    Tacket CO, Losonsky G, Livio S, et al. Lack of prophylactic efficacy of an enteric-coated bovine hyperimmuune milk product against enterotoxigenic Escherichia coli challenge administered during a standard meal. J Infect Dis. 1999; 180:2056-2059.

    Warny M, Fatimi A, Bostwick EF, et al. Bovine immunoglobulin concentrate-Clostridium difficile retains C. difficile toxin neutralizing activity after passage through the human stomach and small intestine. Gut. 1999; 44:212-217.

  4. #4
    ................ aProtege's Avatar
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    Nah, Im not sure on his logic on this one... its more for immune system building. It is said to have stamina, enegry properties; which could help if your crashing.

    It also supposed to aid in healing, like constent muscle tear from working out.

    I sell this product to a lot of elderly people... they comment its the only thing that helps them in thier old age.

    If your going to use it stick with Jarrow or New Life. (Brands)

  5. #5
    Olympian Bodybuilder DocJ's Avatar
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    Sorry, I'm fairly sure on this one, it's not getting absorbed. The only reason it does in infants/calves is because their digestive systems are very porous in the first few months of life. This is why colostrum is found in high concentrations in breast milk.

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