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  1. #1
    masshole clman8585's Avatar
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    B6 for prolactin supression
    Does anyone have any experience with using b6 for this specific reason? Pls don't tell me to go buy prami or caber. This is just a question...

  2. #2
    masshole clman8585's Avatar
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    Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe: One human study showed a single 300mg dosage of B6 exerts ***8216;a hypothalamic dopaminergic effect***8217; which causes a ***8216;significant decrease of plasma prolactin***8217;(1); Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: ***8216;The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level***8217;(2); Another study found B6 to significantly reduce ***8216;opioids-induced hyperprolactinemia***8217;(3); This study on men found that ***8216;Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise***8217;(4); And a study on male rats found that, ***8216;Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)***8217;(5). [Note: The last study shows B6 to be less effective than Bromocriptine as a prolactin inhibitor but, stacked with vitamin e and SAM-e, along with some of the secondary prolactin inhibitors I list at the bottom of the page, effects comparable to bromocriprine can be achieved.] The vast majority of people receive the very low RDA for vitamin b6 (2mg) from their diets so this isn***8217;t an issue of correcting a deficiency. It appears, instead, that extra vitamin B6, i.e. around 600mg spread throughout the day, acts in a drug like manner to lower prolactin levels. It***8217;s important to realize, however, that the RDA for B6 is set extremely low and many people benefit from getting considerably more than 2mg per day of this vitamin. Vitamin B6 in high doses has been shown in studies to: - Reduce high blood pressure. - Improve mood and combat depression - Lower blood sugar levels in diabetics - Act as an effective calcium channel blocker A very high dose of B6 may act as a prolactin inhibitor in certain people by correcting a functional deficiency of this vitamin that can occur. Inflammation in the body can create a greater demand for B6 so bodybuilders and athletes may require more of this vitamin. Pyrolurics, according to Dr. Carl Pfeiffer and Dr. Abram Hoffer, have an increased need for zinc and B6. People suffering from this illness create abnormally high levels of chemicals called kryptopyrroles, which bind to zinc and B6 in the body, creating deficiencies in both. The standard treatment for pyroluria is high dose zinc and B6 supplementation, typically 50-150 mg and 250-1500 mg respectively (way above the RDA for both).

    Side effects: High doses of B6 taken for many months can cause nerve problems such as tingling in the fingers and numbness in the toes (peripheral neuropathy); B6 can also worsen sleep quality in some people and cause vivid dreams. Fortunately, these problems completely resolve once B6 supplementation is stopped and, since it is water soluble, this won***8217;t take too long.

    Ways around these side effects: One way to avoid the ***8216;finger tingling***8217; that high dose B6 can cause is to take the activated form of B6 called Pyridoxal-5-Phosphate (P5P) - the activated form of B6 does not cause these nerve issues. In fact, the reason that high dose B6 causes nerve problems is that the body can***8217;t always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P.

    Recommended dosage: To lower prolactin levels I would recommend you take 50 to 200mg of P5P a day, in divided doses. If you want to take regular B6, which as I've mentioned can sometimes cause minor side effects, take 300 to 1000 mg per day in divided doses. Read the label before you buy B6 because the Pyridoxine Hydrochloride type of B6 (in most supplements) has been shown to be a prolactin inhibitor but Pyridoxal hydrochloride has been shown to be ineffective at lowering prolactin (6) ***8211; make sure you buy the right type!

  3. #3
    My Wifey Truushot's Avatar
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    I have said to do this for quite a while. I swear by it.

  4. #4
    O
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    So vitamin B6 could be used instead of prami/caber on a tren cycle?

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    Performance Trainer. SicVic's Avatar
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    Hell yeah, thats madd awesome. Better then spending a Ton of money on Caber.

  6. #6
    Performance Trainer. SicVic's Avatar
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    Quote Originally Posted by O View Post
    So vitamin B6 could be used instead of prami/caber on a tren cycle?


    Depends how high your running.

  7. #7
    O
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    Interesting, that would definitely save some cash

  8. #8
    city of the sun Rida5d's Avatar
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    Interesting post .. B6 is cheap compared to dostinex

  9. #9
    city of the sun Rida5d's Avatar
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    Scared to trust b6 with prog Gyno.. That Gyno is a biaatch

  10. #10
    Novice Tyty88's Avatar
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    I know this is old thread but I'm planning on running tren for the first time on my next cycle (about a year away) I will be running it at 75mg eod and moving up to 100mg if need be. I like this Idea of b6 do you think I could get away with it at those doses? I can find lots of talk a out it but not much on folks who have actually run the b6 instead of prami/ caber

  11. #11
    Amateur Bodybuilder GoPro's Avatar
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    Good read.

  12. #12
    blood&guts
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    600mg ed is my sweet spot.

  13. #13
    Grrr...tren Good SolomonGrundy's Avatar
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    I'd tried 300 a day after reading an old classic on here , it works

  14. #14
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    Should b6 be taken in one dose or spread threw out the day, any suggestion would be much appreciated

  15. #15
    Novice Tyty88's Avatar
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    Thanks guys

  16. #16
    Junior Bodybuilder Krazydiamond's Avatar
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    Great read, may have to add this into tren/test/mast run

  17. #17
    Olympian Bodybuilder APOLLON's Avatar
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    Take it with a meal?
    How bout the 5 pyridoxal phosphate version?
    How bout x2 250 mg capsules at once is it ok?

  18. #18
    masshole clman8585's Avatar
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    ^read last paragraph
    APOLLON likes this.

  19. #19
    Amateur Bodybuilder
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    is b6 an injection like b12? or tablet?

  20. #20
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    I have heard it can help. May have to give it a try if i run into any issues

  21. #21
    Olympian Bodybuilder APOLLON's Avatar
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    Quote Originally Posted by clman8585 View Post
    ^read last paragraph
    Nice!
    Now which brand do you recommend?

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