Peptides: Tissue Growth & Protection and Practical use surrounding them *A MUST READ*

[juced_porkchop]

Peptides, Tissue Growth & Protection and Practical use surrounding them

Hello all of you in internet land!
Today I wish to cover the subject of peptides and their possible uses.
There seems to be a lot of people out there unsure of what peptides are or flat out think they are some sort of gimmick.
I was at one point in time in the same boat, so no worries keep reading and you might learn something. After many years of research on this topic and countless personal experiences with peptides I feel I am qualified to try to help others out there by putting together this article covering the most popular peptides, their uses, how to use them safely and most effectively.

What so WHAT in the world is a PEPTIDE???

Isn***8217;t that the stuff in my wife***8217;s shampoo???

Well***8230;***8230; I might be. But not all peptides are the same! Just like not all amino acids are the same.
Peptides are actually very similar to amino acids (protein molecules) believe it or not.
A peptide is a short, large molecule of an amino acid molecule that can bind chemically to other molecules to form a larger molecule by peptide bonds. They are listed as a peptide or protein depending on their size.

I know it sounds confusing and in some ways it is. But it is not too hard to understand them.
There are many kinds of peptides out there some are your basic protein type peptide that I will not bother to cover at this time or that would make this more of a diet article than a peptide article. Another is a ***8220;peptide hormone***8221; they are secreted into the blood stream and have an endocrine function in the body.[1]

There is even something called a neuropeptide. One of many for e.g. is DSIP (Delta Sleep-inducing Peptide). They are small protein-like molecules used by the neurons to communicate.
They are much smaller than a neurotransmitter and are considered neuronal signaling molecules and they affect many functions in the brain like; pain, hunger, memory and can even effect you***8217;re learning abilities!
Still think Peptides might be a gimmick? HA I sure don***8217;t. I think they are GREAT!
No I won***8217;t be talking about neuropeptides today, but I wanted to at least mention them because I feel they are pretty cool and very important.


Today I will be talking about Peptide Hormones!

Peptide hormones are not the same as steroid hormones.
Steroid hormones are synthesized from cholesterol, and are lipids (they are fat based). While peptide hormones are proteins and are formed by a sequence of amino acids.
As mentioned above these are the ones that have physical effects on the body like growth and repair and has been of very big interest to the bodybuilding scene and in recent years I feel at a massive scale due to the internet and many places selling these peptides.
I felt I really should put something together about these powerful peptides and how they might help you in your quest to recovery, fat loss and growth.



I will start with the basics of what each one does then I will get into more detail on how you can use them safely and effectively.

GHRP-2
Is a human growth hormone secretagogue. That means it stimulates the body's own release of HGH. It is a ghrelin receptor agonist is also seems to have some protective effect on some tissues and an anti-inflammatory effect as well. The excessive hunger some feel with Ghrp-6 use does not seem to be an issue with GHRP-2. The half-life is about 20 minutes so multiple doses per day are optimal.

Ghrp-6
Is also a human growth hormone secretagogue and stimulates the body's own release of HGH. It is a ghrelin receptor agonist and also seems to have some protective effect on some tissues and an anti-inflammatory effect as well. The half-life is about 20 minutes so multiple doses per day are optimal.
*Note: Ghrp-6 seems to cause excessive hunger in some people compared to GHRP-2. It is not a bad thing per say but depending on if your bulking or cutting you may prefer one over the other.

cjc-1295
Is a growth hormone releasing hormone (GHRH) and it aides in the stimulation of the pituitary gland to increase production of growth hormone and stimulates GH and igf-1 secretion. It will keep a steady increase of HGH without an increase in prolactin as can be an issue for some peptides of this nature. It is an analog to a peptide that is naturally produced to stimulate pituitary production of growth hormone. It has a half-life of about 7-10 days. This means once a week dosing is optimal in most cases.

CJC-1293
Is also a growth hormone releasing hormone (GHRH) and it aides in the stimulation of the pituitary gland to increase production of growth hormone and stimulates GH secretion. It is an analog to a peptide that is naturally produced to stimulate pituitary production of growth hormone. The GH pulse from a single administration of CJC-1293 is much greater than that of cjc-1295 but duration is shorter. There is debate on which is better but both are useful regardless.

IGF1 Des
igf-1 Des is an igf-1 analogue of our native igf1 with the last 3 amino acids in the igf-1 chain removed. That leads it to have little protein binding (good thing), but similar action causing it to be about 10 times more potent than normal igf-1.[2] The active life is still fairly short, only about 20 minutes making multiple doses daily optimal for some users while others still feel once a day dosing is still worthwhile and the way to go.

IGF1LR3
Is also an IGF1 analogue with a 13 amino acid extension at the N-terminus. The alteration leads to less binding in the body greatly extends its half-life from 20min to about 20+ hours. Once a day dosing is optimal.

IGF1Ec / Mechano Growth Factor (MGF)
IGF1 Ec is derived from IGF-I but its effects differ from the systemic IGF-I produced by the liver. It is released as a pulse following muscle damage, is involved in the activation of muscle stem cells and also seems to protect the myocardium against ischaemia, which improved cardiac function after heart attacks. There is debate on dosing but i feel post workout (once daily even on non workout days) is a good way to go about it.[3]

MT2
Melanotan II (MT2) is a melanocortin. Melanocortins (MCs) are a family of multifunctional peptidergic hormones. MT2 is an analog of these and plays a role in the tanning process but will vary between skin types with its use. It is not really used in any growth as HGH or igf1 would be, but I feel due to its potential skin protection that I should add it in this article even if tanning is not the main focus of this article.



As you can see all this stuff seems to revolve around IGF1 and HGH, so to understands its effects does not mean needing to fully understand each and every peptide (though a basic knowledge should be known about each one you use). Each peptide is working as either an IGF1 analog or as a HGH releaser and HGH converts to IGH1 giving most of its tissue growing effects anyway.

It***8217;s more understanding what IGF and HGH do in the body, to fully understand what these peptides can potentially do for you.

I would like to talk mainly about IGF1 as I feel it is the main cause for growth over that of HGH solely.[4]
The liver is the organ mostly responsible for the production of serum IGF-I even when taking exogenous HGH it is still mainly converted in the liver.

igf-1 acts differently in different types of tissues its not all tissues grow from its effects. When active in muscle cells and associated cell***8217;s they stimulate growth by increasing protein synthesis along with amino acid absorption. igf-1 also plays a role as a source of energy; IGF mobilizes fat for use as energy in adipose tissue by preventing insulin from transporting glucose across cell membranes. This results in the cells having to switch to burning off fat as a source of energy which I feel is a great quality about igf-1.IGF also seems to mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects.[5][6]

I think one of the most interesting effect***8217;s IGF has on the body is its ability to cause hyperplasia, that is when an actual splitting of cells occurs leading to more cells. You are basically your growing more cells with the use of HGH and igf-1.
Hypertrophy is what occurs when practising weight training and steroid use. Hypertrophy is simply an increase in the size of muscle cells but not growing new cells. In humans after you are done puberty you mostly have a set number of muscle cells that you have developed with that doesn***8217;t vary much.All you would be able to do is increase the size of these muscle cells, but you don't actually gain more of them.
This is not good for someone with ***8220;bad genetics***8221; in the area of muscle cells.
With IGF use you are able to cause hyperplasia which increases the number of muscle cells and gives you the ability to change your genetic capabilities in terms of muscle tissue and cell count.[6]
Being able to alter a person***8217;s capacity to build muscle density and size is an awesome thing to have control over.
When you do a ***8220;cycle***8221; of HGH releasing peptides or even straight use of IGF1 analogs on its own, you not only add to growth and recovery while on them, you give yourself a greater number of cells to work with and down the line grow then.

When you finish a cycle of igf-1***8230;. in a way you are not really finished because you are still left with these new cells regardless of stopping the use of IGF1 or HGH releaser peptides and that is one of the things I just LOVE about HGH and IGF1. The fact you have residual effects is awesome for muscle building!


OK, OK we know igf1 causes growth of size and cells, but how do I use this stuff effectively?
Well by knowing the basics of each peptide, how they might have a synergy when used together and fully understanding the effects of HGH and igf1 that***8217;s how!

Unfortunately a lot of the use of IGF1 and HGH by bodybuilders and athletes is an underground trend of their use and you might not find some of the info needed to stack them optimally together or use them in a home setting.
I wish to give you some of that information here.

Secretagogues are different from GHRH's, they share no sequence relation and derive their function through action at a different receptor and it has been established that the use of Growth Hormone Releasing Hormone (CJC1295 is one for e.g.) and a Growth Hormone Releasing Peptide (Ghrp-6 or GHRP-2 for e.g.) together results in synergistic release of GH from pituitary.
It is like saying 2+2=5 not 4, if you get what I am trying to say.

I strongly rec stacking a GHRP with a GHRH for optimal results in tissue growth and fat loss, even if also using an IGF1 analog in the same cycle as some like to do.


Here are some good examples of ***8220;peptide cycles***8221; (Taken Sub Q):

1#
Wk1-8 40mcg ed igf-1LR3

2#
Wk1-12 1000mcg (1mg) every week cjc-1295
Wk1-12 100mcg 2-3X ed GHRP-2 or Ghrp-6
Wk1-12 10-20mcg ed IGF1 Ec (post workout***8217;s)

3#
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or Ghrp-6

4#
Wk1-8 40mcg ed igf-1LR3
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or Ghrp-6

5#
Wk1-8 10-20mcg 1-2X ed igf-1 Des

6#
Wk1-8 10-20mcg 1-2X ed igf-1 Des
Wk1-12 100mcg 2-3X ed CJC-1293 (CJC w/o Dac)
Wk1-12 100mcg 2-3X ed GHRP-2 or Ghrp-6

7#
Wk1-8 10-20mcg 1-2X ed igf-1 Des
Wk1-12 1000mcg (1mg) every week cjc-1295 (Sub Q)
Wk1-12 100mcg 2-3X ed GHRP-2 or Ghrp-6

8# (MT2 cycle is for tanning purposes only, dependent on skin type and these are guidelines only)
Wk1-4 0.5mg 2-3X a week of MT2 (10min tan every week)
Wk4-8 0.5mg 1X a week of MT2 (10min tan every other week)
Wk8-? 0.5mg 1X a month of MT2 (tan and dose as needed) *maintenance

These cycles above would be optimal ways of using these peptides for muscle growth and fat loss.

Using one or more of the HGH releasing peptides along with an IGF peptide like igf-1LR3 could lead to growth and more fat loss over just the use of igf-1LR3.
But the use of one or more of the HGH releasing peptides without igf-1 could lead to less total gains in mass as well. So stacking is goal dependent.
I feel they stack together very nicely personally and I highly recommend IGF1LR3 to my friends new to and interested in peptides.

IGF1lr3 or IGF1 Des are good peptides to start out with due to the simple ease of their.
Then once you feel comfortable I would highly recommend stacking it with one of the GHRP***8217;s and GHRH***8217;s for maximum results.

There are new discoveries every day in the field of ***8220;the human body***8221; and I would be VERY Happy If I had some effect on this knowledge spreading, so I hope you learned something and enjoyed my article on these peptides and how to use them most effectively and safely.

I look forward to helping all I can and making more of these kinds of informative articles.
Till the next time,







Take care!









References:
1) Peptide Hormone Secretion/Peptide Hormone Action: A Practical Approach 2 Volume Set Author: K.Siddle, J. C. Hutton, Oxford University Press, 1991
2) Des(1***8211;3)igf-1 Treatment Normalizes Type 1 IGF Receptor and Phospho-Akt (Thr 308) Immunoreactivity in Predegenerative Retina of Diabetic Rats A. Kummer,1 B. E. Pulford,2 D. N. Ishii,2 and G. M. Seigel11University of Rochester School of Medicine and Dentistry, Rochester, New York, USA 2 Colorado State University, Fort Collins, Colorado, USA
3) Heart Lung Circ. 2008 Feb;17(1):33-9 Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C. Source Waikato Clinical School, Private Bag 3200, Hamilton, New Zealand. Mechano-growth factor reduces loss of cardia... [Heart Lung Circ. 2008] - PubMed - NCBI
4) The somatomedin hypothesis: 2001.Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892-1758, USA. derek@helix.nih.gov The somatomedin hypothesis: 2001. [Endocr Rev. 2001] - PubMed - NCBI
5) Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.
6) LeRoith D, Yakar S.Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. derek.leroith@mssm.edu

[juced_porkchop]

Just thought I would post this here also since some people only seem to check the AAS section lol

[Tugboatz]

Wow, awesome post!

[Chainman]

Vey interesting, thanks for taking the time to post. Great read!!

[juced_porkchop]

NO prob guys!
Happy someone could use it!

[mlupi319]

Just read this over in the peptide section, Awesome Info!!

[mistah187]

Very Nice post. Been trying g to learn more about peptides the past couple of days so this was good timing.

[livebigdieyoung]

good post! great information!

[grind4it]

Great post. You did a great job of breaking it down, then stacking up.

[mlupi319]

Hey Juced you got any info on fragments? there's what, 2 of them? 177-191 and 176-191...they're supposed to be mainly for fat loss?..how affective are these compared to the peps you've already mentioned?

[UserAt204]

.......,

[600@50]

Been looking for this info all in one place for awhile. Thanks man.

[Mr.Port]

Great post! thanks

[Taylor26]

great read...and a MUST read for anyone interested in peptides. thanks for gathering all this and putting it together J_P.

[juced_porkchop]

Some of the info is a bit old but good basics.

Here's some points to remember that are key:

A ghrh like mod-grf 1-29 or often referred to as cjc1295 w/o dac is a complete waste of time and money on it's own. It will not do anything for you unless you happen to be lucky enough to be in a natural gh pulse, and good luck with that.

A ghrp on it's own will cause a pulse of gh but no where near what it will in combination with a ghrh. Cjc1295 w/DAC (drug affinity complex) is for women. DAC creates a constant release of gh, which is not like a mans natural large pulse. Men do not want to use this. It's called gh bleed where constant low levels are being released.

Men want modified GRF / CJC1295 W/O DAC. This is used in the same pin, at the same time with a ghrp of your choice (ghrp2,ghrp6,Ipamorelin,hexarilin). The 4 of these are interchangeable, and you could use two ghrp's at one time or at different times of day or rotate them.

Ipamorin is a good option because it has essentially no sides. Hexarilin and ghrp 2&6 can cause a rise in cortisol and prolactin in dose dependent amounts. Hexarilin is the strongest of the four but will cause some cortisol and prolactin increase.

With a ghrh, you do not need over 100mcg or it's just a waste, 150mcg as the maximum dose. That is the saturation rate and will not be helpful to increase.

At one time it was thought ghrp's had a saturation dose of 100mcg, meaning anything over that had a diminished return. Well that is not true. 400-500mcg of hexarilin with mod grf 100mcg is a good dose pwo but will increase prolactin and cortisol.

Ghrp2 and ipam can be dosed as high as 1mg at a time (1000mcg) but ghrp2 will cause sides over 200-300mcg as will Ghrp-6.


3 x a day is a very common and good way to use that combination in a dose you can afford. 100/100mcg is effective but not a miracle. Larger doses of the ghrp make it better but more expensive and possible sides. At a point it may be cheaper or just the same to get gh if you can find real gh.

These IMO should be used for several months at a time like gh or continuously to receive the true benefits. They take time to work but have been documented in medical studies to increase gh for 1-2 hours where it peaks then steadily declines. Exo gh peaks around 5 hours. But they were using medical grade peptides so beware of what you get. If SRC is still a sponsor, he has the best peptides I've used.


Also, people can use these in combination with gh, either an hour before gh or if on a 5 on 2 off schedule, use the peptides on the two off. It's almost like a gh PCT because it forces gh out put.

I personally like igf. Lr3 is thought to lose efficacy after 4 weeks. So typically is 4 on 4 off. A typical dose is 50-100mcg daily. It's thought that igf blunts the action of MGF which occurs naturally after working out so it's thought to be best used hours after training to let MGF do it's thing first then igf complete the process.

Igf DES can be used pretty much continuous and really needs no break. Most use it pre workout due to short half life and incredible pumps it gives in gym.

The good thing about igf is it's an insulin like growth factor. So it should help shuttle nutrients like insulin just not as well, so the point is to load up nutrients during the active window.

There is a lot of confusion on igf and it's role in hyperplasia. At first it was said to cause it. Now many studies aren't agreeing with that and say it may not even play a role in it.

But there is a synergy that comes with the use of peptides, hormones, gh, insulin, and combined at the right times with good doses you can really make some changes.


Most of the articles and protocols on the net are old, if you google igf, peptides, etc you get a ton of old information. So look for medical studies or updated info.

Igf lr3 seems to be beneficial in PCT, I'm not sure on the exact reason but it seems to help with lydeg cells and speed of recovery. It helps maintain some of the pump you had on cycle, possibly glucose disposal, and possibly to help shuttle nutrients into the muscle but adequate doses are necessary.

Juiced-- good work posting some info here since most don't bother with the peptide forum. There is a lot of good info there. SARMS are also effective and useful. Take some time and see what type of info you can find on them and take advantage if you think it can help.

Sorry but I think that is BS bro science. I have used MYSELF cjc1295 (funny I am usin it now also) and can tell you it is not a waste.
also just because females HGH pulse differs from men dosent mean taking a drug that releases HGH over time would give you the effects of the women, this is "bro Science"

It is not old info (maybe my opinion to yours) for the most part.
and it has been showen 100mcg+ IS effective and not a waste, recently (If I find the study I will post it) *edite, sorry you stated this also I think*
Using CJC 1295 is NOT a waste on its own.
I mean yes you get more out of it by stacking it with GHRP's but it is NOT a waste and CJC 1295 is fine to use over CJC1293.
the whole "THIS CJC IS FOR MAN and THIS ONE IS FOR WOMEN" is so unfounded (well founded on the amount/kind of spike "NORMALLY" seen in men vs. women, which is not result drivin) it DRIVES ME CRAZY when I see that posted!
I am not attacking you, I like your post for the most part, just venting lol

Ff you want quick spikes, lots of pinning and short cycles go for cjc 1293 but some people dont want to bother with all the shots and I found using cjc 1295 for 3 months very nice.
Some might just want to pin 1-2 times a week over many months and have the extra HGH, (even older folk)

I agree on the SARMS comment, but thats another post I will be working on so I didnt want to make this one so big that no one bothers to read it.

LR3: I feel using IGF1LR3 anyless then 8 weeks is a waste, from personal exp... 10wks is what i rec normally.



Opinions vary but the basics I am sure we can agree on even with the CJC 1295,... it WILL out put HGH over what you would normally have and that = regeneration and possible new tissue regardless if views on (this for man this for women)
I preferr the CJC 1295 myself.

[juced_porkchop]

Thanks alot guys for all the feed back!

[UserAt204]

Try reading done medical journals and studies along with years of personal experience.

[tballz]

Great post, Juced.....

[juced_porkchop]

Try reading done medical journals and studies along with years of personal experience.

I have read many studies.
One thing you learn when researching is if you look hard nuf where there is one study showing one thing there is another showing the opposite., just saying.

from MY exp and others that have acually used this, (not in a lab study done on rats or small amounts of cancer strickin or old people), I'm sure atleast some would agree they liked the CJC1295, atleast I do anyway and see many reasons for its use. shit even along with HGH..

[juced_porkchop]

I agree if pinning is no issue, money is no issue and time is no issue, CJC 1293 + GHRP2 or 6 would yeld more gains in 3 months then CJC 1295 + GHRP in most cases (I beleve so from what I know anyway).

but some can argue: why would you use tbol when you can use dbol or why use test when you can use tren. Other reasons for using compounds (in my oppinion) than just gains.

[juced_porkchop]

Great post, Juced.....

Thank you!
I am happy if it even helps one person! :-)

[UserAt204]

Do me, yourself, and everyone a favor. If you believe that DAC is effective for a male, dose it, then a day later dose your ghrp(must be fasted with peptides but not with gh) then 30-40 minutes later get a gh serum. Then try dosing mod grf no dac and a ghrp again fasted and gh serum, and see where the results are.

With DAC you are not getting the spikes or pulses needed, DAT also agrees to that. And most studies out are using only a ghrh at 2mg.

I'm with you on posting feedback and info to help others but just because you like using dac does not make it the right option. Your body creates pulses of gh for a reason and you have not figured out what the body hasn't.

As far as dosing, again a serum test will show you what is and isn't effective, and individually. There are serum test of ghrp/ghrh combo showing the same results of 5-10 out of gh but more than 100/100 was used. I can tell you from personal experience that 100/100 is average at best and this is with independent lab tested peptides of high purity and not just the claim of independent testing.

Yes you can make the example that a higher dose of xyz will produce more results etc, but the point I'm making is if you are using gh or peptides or hormones for bodybuilding purposes, you need to use effective doses. There is a reason why gh/insulin works so well at specific doses and gh could easily be made to produce a bleed type effect by adding to the amino chain, just like mod grf, added aminos to increase half life, gh can be made to produce a non stop day or week long increase, but it has been proven repeatedly that gh in the make body is from pulses. Yes by using cjc/dac, you will get a pulse when you dose your ghrp, but it's not as high of a spike as the no dac version.

We can all have our own beliefs but I'm just telling guys here do not waste your money on cjc/dac, and you are wasting your money if you don't add a ghrp to it.

This is no attempt to discredit JP, and I honestly am over posting for any reason. I don't claim to know everything and don't think anyone knows all there is to know about many of the things we use but testing will give proven results, top athletes who use the drugs do so in specific ways for a reason.

If you are over 35 then 100/100 is good anti aging doses but double is more realistic. For a younger guy or a bodybuilder who wants to build mass and benefit to the fullest while still being safe then look at the protocols you find, and test them yourself with labs and see what works. I've been fortunate enough to have been given more than a full years worth of igf, ghrh, ghrp and have been able to use any dose I want and all without ever being a rep for a peptide company. My use is just for my personal experience, what I posted involves that but also based upon how these work in the body and how the male body functions.

So for me it's a dead issue, everyone can do as they please.

[juced_porkchop]

Its all good opinions differ.
I have seen the argument on (CJC1295 is not good to use, it pulses like a womens HGH) *some say that about anavar but I like that too!
but yes a bit too much $ unless you are getting bulk powder var. I also se;, you need big spikes and so on.

So what? Maybe I want a steady stream of GH along with my AAS and GHRP2 to even MK677 with the cjc-1295.
Some might not be able to pin 2-4X a day which is another use.
There are many.
Sure for most just wanting to use short cycles of peptides I agree for a lot they would like 50-150mcg 2-3X a day of CJC-1293 w/o Dac (ModGRF) and GHRP-2.
Just saying I FEEL it is a great peptide with use and long term I plan to use it again along with igf1 (des or LR3) and either GHRP-2, Ghrp-6 or the MK677 (if I end up liking it.)
I DON'T think its a waste (cjc-1295), it depends on your goals and view on the subject.
Its good your posting in here, debate is a good way to learn (on both ends)
I will agree using CJC1295 without GHRP-2 /6 or even the newer oral MK677 is a bit of a waste ( I have recently started MK677 as I am finishing up my cjc1295/GHRP-2,MGF,igf1lr3,MT2 cycle.) MTt2 will continue at maintenance dose for next few months and I will run another igf1lr3 or igf1 des cycle in fall again when I start my bulking.
I will post feedback in another 1-2 months on the MK677 but right now it is too early to say much and also because I have already been using the others.

[UserAt204]

Here's a post from DAT explaining why cjc/DAC is not optimal


Dat explains it very well here :

"You do not want to use cjc-1295. You want to use Modified GRF(1-29).
Why? (Partial Explanation)
"Cell-to-cell communication is also likely to reflect the density and proximity of adjacent cells as GH responsiveness (but not sensitivity) to GHRH is enhanced at higher densities and basal GH release is greatest at low densities."

"Cell-to-cell contact may therefore affect the cellular integrity of somatotrophs because GH synthesis or secretory granule storage may be better maintained in high density cell concentration then in low-density concentrations." - Growth Hormone, Stephen Harvey
What happens is cells in the pituitary communicate. They self organize and create a firing network for coordinated growth hormone release. This communication creates a high density of GH releasing cells. They are in close proximity through their communicatory network. The cells have specific spatial relationships that may be modulated by peripheral endocrines. These include sex steroids, thyroid hormones, glucorticoids and even the pancreatic and gut hormones. Their spatial relationship is also effected by physiological state such as nutrient status, age and pregnancy.

As a quick example, corticotroph, thyrotrophs and folliculostellate cells are in close proximity to somatotrophs and communicate with them through gap junctions (almost like just reaching out and touching signaling). They have the potential to effect and be effected by their neighbors.

What happens when you have GHRH always around is you force these somatotrophs to release GH because they are sensitive to the GHRH binding to them and effecting release. By constantly occupying you are preventing them from coordinating with surrounding cell populations. You force these cells to act as low density subpopulations. Basal GH release is greatest when you can disperse the spatial relationship between somatotrophs and that is what an always on GHRH will do.

cjc-1295 as an always on GHRH will force upon somatotrophs loner behavior with a single constant chore. This reduces GH responsiveness as this only occurs when somatotrophs can communicate, self organize and maintain social relationships with the surrounding community. These types of social somatotrophs are better able to make and store GH then the loner cells.

So cjc-1295 seems to disperse somatotrophs and enslave them getting less from them then if it had just let them congregate in towns and cities.

Aging has an effect on the vitality of city centers as well and as we age these somatotroph population centers become less vigorous. By using a more physiological GHRH such as modified GRF(1-29) together with a modulator GHRP-2 we revitalize that inner city and allow our cells to be more social and thus more productive. If instead we choose to use cjc-1295 we not only fail to remedy the problem associated with age , but we may end up exacerbating it.

I conjecture that it also makes them better neighbors to corticotroph, thyrotrophs and folliculostellate cells as well."
Share
| Like

[juced_porkchop]

That is a note worthy view, thanks for the post!
ALL debate is welcome here, thats how we all learn.