Anabolic steroids, bodybuilding discussion forums. - Steroidology

 

(Forum for members to discuss the use of anabolic steroids)

Results 1 to 10 of 10
  1. #1
    Community Veteran
    DO / AllThingsMale.com

    Join Date
    Jan 2003
    Location
    Lansing, MI
    Posts
    462
    Rep Power
    12
    Hcg Protocol For Trt Patients
    Here it is:

    AN UPDATE TO THE CRISLER HCG PROTOCOL

    By John Crisler, DO



    In my paper “My Current Best Thoughts on How to Administer testosterone replacement therapy (TRT) for Men”, published in A4M’s 2004/5 Anti-Aging Clinical Protocols, I introduced a new protocol where small doses of Human Chorionic Gonadotrophin (HCG) are regularly added to traditional testosterone replacement therapy (TRT) (either weekly IM testosterone cypionate or daily cream/gel). The reasons and benefits of this protocol are as follows, along with a new improvement I wish to share:

    Any physician who administers testosterone replacement therapy (TRT) will, within the first few months of doing so, field complaints from their patients because they are now experiencing troubling testicular atrophy. Irrespective of the numerous and abundant benefits of testosterone replacement therapy (TRT), men never enjoy seeing their genitals shrinking! Testicular atrophy occurs because the depressed LH level, secondary to the HPTA suppression testosterone replacement therapy (TRT) induces, no longer supports them. It is well known that HCG—a Luteinizing Hormone (LH) analog—will effectively, and dramatically, restore the testicles to previous form and function. It accomplishes this due to shared moiety between the alpha subunits of both hormones.

    So, that satisfies an aesthetic consideration which should not be ignored. Now let’s delve into the pharmacodynamics of the testosterone replacement therapy (TRT) medications. For those employing injectable
    testosterone cypionate, the cypionate ester provides a 5-8 day half-life, depending upon the specific metabolism, activity level, and overall health of the patient. It is now well-established that appropriate testosterone replacement therapy (TRT) using IM injections must be dosed at weekly intervals, in order to avoid seating the patient on a hormonal, and emotional, roller coaster. Adding in some HCG toward the end of the weekly “cycle” compensates for the drop in serum androgen levels by the half-life of the cypionate ester. Certainly the body thrives on regularity, and supplementing the testosterone replacement therapy (TRT) with endogenous testosterone production at just the right time—without inappropriately raising androgen OR estrogen (more on that later)—approximates the excellent performance stability of transdermal testosterone delivery systems for those who, for whatever reason or reasons, prefer test cyp.

    But there’s another ********* reason to employ this protocol. The P450 Side Chain Cleavage enzyme, which converts CHOL into pregnenolone at the initiation of all three ********* pathways CHOL serves as precursor (the sex hormones, glucocorticoids and mineralcorticoids), is actively stimulated, or depressed, by LH concentrations. It is intuitively consistent that during conditions of lowered testosterone levels, commensurate increases in LH production would serve to stimulate this conversion from CHOL into these pathways, thereby feeding more raw material for increased hormone production. And vice versa. Thus the addition of HCG (which also stimulates the P450scc enzyme) helps restore a more natural balance of the hormones within this pathway in patients who are entirely, or even partially, HPTA-suppressed.

    It is important that no more than 500IU of HCG be administered on any given day. There is only just so much stimulation possible, and exceeding that not only is wasteful, doing so has important negative consequences. Higher doses overly stimulate testicular aromatase, which inappropriately raises estrogen levels, and brings on the detrimental effects of same. It also causes Leydig cell desentization to LH, and we are therefore inducing primary hypogonadism while perhaps treating secondary hypogonadism. 250IU QD is an effective, and safe, dose. After all, we are merely replacing that which is lost to inhibition.

    In my previous report I recommended 250IU of HCG twice per week for all testosterone replacement therapy (TRT) patients, taken the day of, along with the day before, the weekly test cyp injection. After looking at countless lab printouts, listening to subjective reports from patients, and learning more about Human Chorionic Gonadotropin (HCG), I am now shifting that regimen forward one day. In other words, my test cyp testosterone replacement therapy (TRT) patients now take their HCG at 250IU two days before, as well as the day immediately previous to, their IM shot. All administer their HCG subcutaneously, and dosage may be adjusted as necessary (I have yet to see more than 350IU per dose required).

    I made this change after realizing that the previous HCG protocol was boosting serum testosterone levels too much, as the test cyp serum concentrations rise, approaching its peak at roughly the 72 hour mark. The original goal of supporting serum androgen levels with HCG had overshot its mark.

    Those testosterone replacement therapy (TRT) patients who prefer a transdermal testosterone, or even testosterone pellets (although I am not in favor of same), take their HCG every third day. They needn’t concern themselves with diminishing serum androgen levels from their testosterone delivery system. These patients will, of course, notice an increase in serum androgen levels above baseline.

    While Human Chorionic Gonadotropin (HCG), as sole testosterone replacement therapy (TRT), is still considered treatment of choice for hypogonadotrophic hypogonadism by many , my experience is that it just does not bring the same subjective benefits as pure testosterone delivery systems do—even when similar serum androgen levels are produced from comparable baseline values. However, supplementing the more “traditional” testosterone replacement therapy (TRT) of transdermal, or injected, testosterone with HCG stabilizes serum levels, prevents testicular atrophy, helps rebalance expression of other hormones, and brings reports of greatly increased sense of well-being and libido. My patients absolutely love it. As time goes on, we are coming to appreciate HCG as a much more powerful--and wonderful--hormone than previously given credit.


    Copyright John Crisler, DO 2004. This article may, in its entirety or in part, be reprinted and republished without permission, provided that credit is given to its author, with copyright notice and www.AllThingsMale.com clearly displayed as source. Written permission from Dr. Crisler is required for all other uses.

  2. #2
    RJ
    RJ is offline
    On Vacation RJ's Avatar
    Join Date
    Nov 2003
    Posts
    5,877
    Rep Power
    18
    Gret post Swale.

    So are you saying that instead of just randamly twice a week, take a 250iu shot two days before my cyp IM injection, and the day before. I am getting ready to start HCG through the next 20weeks of my cycle. I take shots of CYP/EQ on Mon/Thurs but I am taking Tren ED at 75mg. When do you think is the best time to administer the Human Chorionic Gonadotropin (HCG)?

    Thanks

  3. #3
    Community Veteran
    DO / AllThingsMale.com

    Join Date
    Jan 2003
    Location
    Lansing, MI
    Posts
    462
    Rep Power
    12
    This is for testosterone replacement therapy (TRT) patients. The Anabolic Androgenic Steroids (AAS) users would probably do well to take their HCG every thrid day. My Anabolic Androgenic Steroids (AAS) patient who have done that report back that it works better that way.

  4. #4
    RJ
    RJ is offline
    On Vacation RJ's Avatar
    Join Date
    Nov 2003
    Posts
    5,877
    Rep Power
    18
    Originally posted by SWALE
    This is for testosterone replacement therapy (TRT) patients. The Anabolic Androgenic Steroids (AAS) users would probably do well to take their HCG every thrid day. My Anabolic Androgenic Steroids (AAS) patient who have done that report back that it works better that way.
    Sorry, forgot the thread name.

    I'll do that every 3 or 4 days like normal. Thanks for the great post!!

  5. #5
    Community Veteran DADAWG's Avatar
    Join Date
    Feb 2003
    Posts
    22,960
    Rep Power
    269
    thanks swale
    NOT ONLY IS STUPIDITY INCURABLE BUT ITS ALSO CONTAGIOUS OVER THE INTERNET.

    VAR ONLY CYCLES ARE ONLY FOR PEOPLE WITH A VAGINA.

  6. #6
    Amateur Bodybuilder Flex it's Avatar
    Join Date
    Jan 2003
    Posts
    707
    Rep Power
    12
    Originally posted by SWALE
    This is for testosterone replacement therapy (TRT) patients. The Anabolic Androgenic Steroids (AAS) users would probably do well to take their HCG every thrid day. My Anabolic Androgenic Steroids (AAS) patient who have done that report back that it works better that way.
    Still 250iu?, or 500iu?

  7. #7
    Community Veteran
    DO / AllThingsMale.com

    Join Date
    Jan 2003
    Location
    Lansing, MI
    Posts
    462
    Rep Power
    12
    Most testosterone replacement therapy (TRT) patients get by just fine with 250IU's. Probably the Anabolic Androgenic Steroids (AAS) users would do more, but never more than 500IU's at a time.

  8. #8
    Novice
    Join Date
    Aug 2007
    Posts
    101
    Rep Power
    8
    good job swale .... well i'm in 3rd week of my 1st sus 250 cycle, i take my shot every tuesday... nd took Human Chorionic Gonadotropin (HCG) 500i.u this saturday after my 3 rd shot so can i take Human Chorionic Gonadotropin (HCG) next with my shot ..... nd any idea on till what time can i keep Human Chorionic Gonadotropin (HCG) after mixing the salt and liquid ?

  9. #9
    FNG Tapeworm's Avatar
    Join Date
    Apr 2008
    Posts
    92
    Rep Power
    7
    Refrigerate it in syringes after reconstitution. I think 60 days is the recommended max.


    Good stuff Swale. Thanks.

  10. #10
    Novice
    Join Date
    May 2006
    Posts
    67
    Rep Power
    9
    swale
    in your previous post re Human Chorionic Gonadotropin (HCG) protocol (now in the "classics") you stated that "In fact, I wouldn’t mind having a guy use 250IU per day ALL THROUGH the cycle" if the usual protocol was unsuccessful in preventing atrophy. does that advice still hold true given this new recommendation?

uniquemicals
Thread Information
Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads
  1. By beaf in forum Anabolic Steroid Forum
    Replies: 10
    Last Post: 02-11-2010, 11:58 AM
  2. By Ozzy27 in forum Anabolic Steroid Forum
    Replies: 5
    Last Post: 01-23-2009, 04:23 AM
  3. By mister.fantastic in forum Anabolic Steroid Forum
    Replies: 3
    Last Post: 08-08-2008, 11:39 PM
  4. Replies: 9
    Last Post: 12-23-2005, 01:29 PM
  5. By bigmack69 in forum Anabolic Steroid Forum
    Replies: 3
    Last Post: 06-16-2003, 11:47 PM
Tags for this Thread
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
  

3Js Nutrition Network

juicepump











solid muscle isolate 5lb

3Js Nutrition Network

solid muscle isolate 5lb

health and fitness talk