[juiceman2027]

hear drinkin grapefruit juice with the orals creates a longer halflife or something with the enzymes or something
/ can anyone shine some light on this for me?

[Shaptown]

Im going to give you a sweeping generalized analogy here:

DO NOT drink grapefruit juice when taking any medication that is metabolized by the liver.

Many drugs are metabolized by Cytochrome P450 CYP3A4. So is grapefruit juice.

Drink grapefruit juice will cause the cytochrome to utilize grapefruit juice as a substrate rather than the xenobiotic that you have ingested. This will indeed cause a longer half-life of the unmetabolized xenobiotic. It too will cause increased general toxicity to tissue with affinity for deposition of the ingested substance.