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  1. #1
    Hi Perfection Awaits's Avatar
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    Epistane: The next generation of hormones: Methylated epitiostanol
    [SIZE="4"]YLEGAL TO BUY:

    I have created this compilation of information in order to help educate people about this chemical and how they can benefit from it.

    The first thing that people should know about this, is that it's legal. You can buy it from many supplement companies. I always get it from BN or Nutraplanet (they usually have sales/deals/other good stuff).

    I'd also like to say that this should be used just like any steroid. Just because it is sold at supplement stores doesn't mean it's OK to take when you're 135lbs and 18 years old.

    How can Epistane be used?

    Epistane can be used in many ways. A lot of people run it alone with good results. Our own "getfitdoc" has gained ~15lbs from his latest cycle. It can also be used at the beginning or end of a cycle, just as any other oral is used.

    If you are running this with long esters, such as Test e, you could run it at the beginning to help kick-start your cycle, or save it for the last four weeks to get you a boost at the end of your cycle. It will help to shed some water weight before coming off, and getting your estrogen under better control right before post cycle therapy (pct) starts.

    No matter what way you use it, the dosing is up to you. My advice is to start low, and see how your body reacts. People have seen results from as low as 20mg per week, but the average dose is 30-40mg/week. Like any oral, this should not be taken for more than 4-6 weeks.

    Sample Stand Alone Cycle:

    Week 1: 30mg/day
    Week 2: 30mg/day
    Week 3: 30mg/day
    Week 4: 40mg/day
    post cycle therapy (pct)

    Or

    Week 1: 40mg (start at 10mg first day and move up 10mg each day)
    Week 2: 40mg
    Week 3: 40mg
    Week 4: 40mg
    post cycle therapy (pct)

    Here is an example of two very useful ways to take it on a Test E cycle.

    Cycle 1:
    Week 1-4: Epistane (See above for dosing)
    Week 1-10: Test E
    post cycle therapy (pct) 2 weeks after last Test E dose

    Cycle 2:
    Week 1-10: Test E
    Week 9-12: Epistane (see above for dosing)
    *The goal here is to start epistane exactly 2 weeks before your LAST Test E injection. Take epistane for 4 weeks, last the 2 weeks that you are not injecting the test is still in your system. Start post cycle therapy (pct) the DAY AFTER your last epistane dosing, which should also be EXACTLY TWO WEEKS AFTER you last Test E dosing.

    Do I need to do a post cycle therapy (pct) with Epistane?

    YES. Proper post cycle therapy (pct) needs to be ran just like any other cycle.

    Epistane Side Effects

    Like any other oral compound, some damage will be done to your lipid profile while you're taking this. The advantage that Epistane has over other orals, is that your body can recover from the lipid profile issues very shortly after you stop taking Epistane. To help with this while on cycle, I personally recommend Milk Thistle and NAC, or look into Anabolic Innovations product Cycle Support, and Post Cycle Support to use in post cycle therapy (pct). I believe at BN and NP you can find these in a package and save some money.

    Many people who worry about their hairline don't need to worry while on Epistane. It is not a DHT derivative and is NOT hard on your hairline.

    What are the benefits?

    Most people experience lean muscle gain when taking this. Most people who have used both Anavar and Epistane will say that they have very positive effects. The two are not similar chemically, but very similar with the positive effects it will have on your body.

    It also works very well as an anti-estrogen. No...it should NOT be used during post cycle therapy (pct), but people who take it while taking other compounds notice great anti-estrogenic properties (loss of bloating, gyno reduction, acne reduction, etc).

    From IronAddict:

    Epistane is one of the newest designer steroids on the market today, and it is gaining attention very quickly. Epistane is actually a methylated version of the controlled substance Epitiostanol (2,3-Epithio-5-androstan-17-ol), which was created in the 1960's and used as a treatment for breast cancer. Since the only place Epitiostanol is only availabe at this time is in japan, chemists added a methyl group to the compund and the final product was a substance now known as Epistane. Epistane is a sulfur containing steroid which is known to have strong and long lasting anti-estrogenic activity as well as weak androgenic and mytropic activities.

    What you can expect?

    Since it is designed to be anti-estrogenic you can expect very dry gains from this compound. Epistane has low androgenic to anabolic activity. This meaning that it is much more anabolic then androgenic. Thus making sides very minimal to non existant from this substance. Also one of the great properties of this substance is that it does a great job in keeping the natural suppression of the gonads away. Since it has anti-estrogenic properties it keeps your LH levels elevated and it is also said both through science and human trial that epistane may have the ability to reduce gyno. This is still a widely debated outcome of epistane but is actually showing more and more positive results as it becomes more popular. Even though users will see dry gains on epistane it does not mean that it would be any insufficient for a bulking cycle. In fact it would be beneficial because it would generate lean gains. Through research it is reported that most users who have taken this substance have gained anywhere from 5-12 lbs in a 3-5 week cycle. Now in my opinion epistane would be better in a cutting cycle to keep the body dry while preserving and potentially add more lean muscle tissue.




    People also experience a libido increase. Granted if you are stacking this with other compounds it is not guaranteed. The parent compound of Epistane is epitiostanol. This drug is used in japan as a libido increaser. Here is a study on the parent compound epitiostanol.

    [A case of advanced breast cancer successfully tre...[Gan To Kagaku Ryoho. 1988] - PubMed Result

    A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.

    By methylating epitiostanol, it becomes orally bioavailable, just like every other oral steroid. Hence...Epistane.

    Here are some blood results from people who were running epistane while getting bloodwork.

    2006 Epi Bloodwork (20-45mg linear ramp):
    SuperSoldier & Dr.D

    _______________SS_____________________Dr.D
    Date: ...1/07.....1/16.....1/26.................1/01.....2/09

    AST ......26........32.........41...................24 ........52
    ALT ......31........39.........51...................20 ........45
    GGT ......09........05.........07...................15 ........21

    ALB.......4.0........3.8........3.9............... ..4.5.......4.8
    TBIL......1.8........1.1........1.3............... ..0.6.......0.5
    DBIL......0.3........0.3........0.2............... ..NA........NA

    CHOL.....145.......149.......171.................1 99......208
    LDH.......156.......198.......208................. 129......147
    HDL........32.........19.........9................ ...30........26


    The following is a nice write-up from LakeMountD:

    How Epistane Works

    Battling Gyno

    Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ER***945; and ER***946;). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane***8482; works by binding and deactivating the ER***946; so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ER***946; is the primary target receptor responsible for growth and proliferation. Epistane***8482; binds to the ER***946; and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ER***946; receptor and AI***8217;s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane***8482; has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.

    Increasing Lean Body Mass

    Epistane***8482; also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.

    Here is the Product Description

    Epistane***8482;


    Finally the PRO-Anabolic, anti-estrogen we have all been waiting for has arrived! Epistane***8482;, exhibits a strong, long lasting anti-estrogen effect that is organ tissue specific. This means it works only where you want it to work. Broad range estrogen blockers and aromatase inhibitors can result in system shut down, aching joints, and decreased IGF-I expression. Epistane***8482; binds specifically to the 17***946;-estradiol receptor protein in the target tissues. Because of its long lasting and strong effects on specific tissue, Epistane***8482; can significantly reduce and reverse the effects of gynocomastia because not only does Epistane***8482; specifically block estrogen in breast tissue but it induces an estrogen-depleted condition which leads to apoptosis or the death of the breast tissue cells. Studies show that small doses of the parent compound, Epitiostanol, at just 10-20mg/week showed a complete disappearance of the mass and pain in 25% of the male patients in the clinical trail, while the other 75% of the patients showed at least a 50% reduction in the mass and complete loss of pain in just 4-8 weeks. That***8217;s results in 100% of the male users with no side effects. While compounds such as Clomid and Nolvadex also block the 17***946;-estradiol receptor, they do not elicit the same increase in protein synthesis and strength gains that Epistane can offer.
    Epistane***8482; is more than an anti-estrogen, though, as it also binds to androgen receptors in skeletal muscle. As a PRO-Anabolic compound Epistane***8482; promotes increases in strength and lean body mass with an anabolic/androgenic value (Q ratio) of 12. With most powerful androgens there is a high risk of the natural suppression of the gonads. Epistane***8482;, unlike other PRO-Anabolic compounds that have recently been released, is relatively mild on the gonads and, due to the anti-estrogenic effects and the fact that Epistane***8482; keeps LH levels elevated, post cycle therapy becomes a breeze. All effects combined make Epistane***8482; a great compound to produce dry, lean gains in muscle mass with minimal side effects and suppression of the body***8217;s natural androgen production, while lowering the effects of natural estrogen or combating estrogen from endogenous/exogenous sources. This makes it a powerful tool when combined with ***8220;wet***8221; compounds in attempt to increase gains and decrease side effects. One can also not overlook the potential benefit of this compound taken alone, especially when recovering from periods of ***8220;wet***8221; compounds. If you don***8217;t want to worry about how your lipid and liver values are doing and whether or not you are going to get gynocomastia or not then get Epistane***8482;, stop worrying, and experience what others are raving about!

    Our Member's Logs!

    getfitdoc: http://www.steroidology.com/forum/my...rkout-log.html

    ManOfMuscle: http://www.steroidology.com/forum/my...stane-log.html

    If anyone else starts a log let me know.

    Epistane and Women

    Epistane has been used by women with great success. Side effects for women have been low. Some prefer it over Anavar since it does not cause bloating. Clitoral enlargement has not been an issue in these women. The most common dosing for women is 10mg EOD, or 10mg ED.

    LEGAL TO BUY:

    PA
    Last edited by Perfection Awaits; 11-02-2009 at 02:23 AM.

  2. #2
    Death Dealer ManOfMuscle's Avatar
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    Have you or anyone you know run this?

  3. #3
    Hi Perfection Awaits's Avatar
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    Yes and yes. With good results. 2 guys had their blood tested. Granted lipid values were elevated, but nothing serious. Most people usually see 10-15lbs gained...usually more close to 10...but they are very lean gains...and very maintainable gains. I am using this for now on as my "oral" steroid. I love anavar, and this is cheaper, easier to get, and slightly more effective.

  4. #4
    Death Dealer ManOfMuscle's Avatar
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    So this is legal?

  5. #5
    "YAAAAA BUDYYYYYY" nickd84's Avatar
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    I have ran Havoc, which is basically the same thing, I think it was just OK. I have read that it has also given people gyno. I personally think that it is way to hyped up! But its just my opinion.

  6. #6
    Hi Perfection Awaits's Avatar
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    It is legal now, to buy...but im sure once mr. FDA gets around to it, it will eventually be gone. But it took them about 3-4 years to get rid of all the old prohormones (ban's take a long time). But it itself, methylated epitiostanol, is a steroid.

  7. #7
    Death Dealer ManOfMuscle's Avatar
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    Sounds more than a little bit too good to be true.

  8. #8
    Hi Perfection Awaits's Avatar
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    Quote Originally Posted by nickd84 View Post
    I have ran Havoc, which is basically the same thing, I think it was just OK. I have read that it has also given people gyno. I personally think that it is way to hyped up! But its just my opinion.
    Havoc is an epistane knock off, so i wouldnt trust what you were taking had the same purity/thing. A lot goes into the chemistry of making these compounds that the typical joe-researcher doesnt understand.

  9. #9
    Hi Perfection Awaits's Avatar
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    Quote Originally Posted by ManOfMuscle View Post
    Sounds more than a little bit too good to be true.
    I liked it...used it standalone. I will be using it with my testosterone replacement therapy (TRT) next. For $40 and to be able to purchase it legally without any worries...It was worth it. I gained 8lbs in 4 weeks with mediocre dieting, and working out 2-3 days a week.

    I kept those 8 lbs for good though

  10. #10
    Death Dealer ManOfMuscle's Avatar
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    That's good to hear. I would shit my pants if this was able to put 8 lean lbs on me.

  11. #11
    Hi Perfection Awaits's Avatar
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    just dont take an 8lb shit

  12. #12
    Death Dealer ManOfMuscle's Avatar
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    Also, you should highlight which parts of this you wrote, and which you didn't. I'm not interested in reading their ads.

  13. #13
    Hi Perfection Awaits's Avatar
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    Ok im on it

  14. #14
    Hi Perfection Awaits's Avatar
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    I just found on Bulk Nutrition, you can get the Cycle Support and Epistane for $75. That saves you $6. Search epistane and you will see the "package".

  15. #15
    Death Dealer ManOfMuscle's Avatar
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    That's better. I knew I was right to skip most of it.

  16. #16
    Hi Perfection Awaits's Avatar
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    lol

  17. #17
    estray
    Guest
    Its good stuff. My wife ran it for a month. Put on around 5lbs got strong as hell.

  18. #18
    Hi Perfection Awaits's Avatar
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    Indeed, i forgot to mention I did gain a ton of strength as well...which is what i was hoping for most...after crashing from a cycle bad last year and losing a lot of it.
    Last edited by Perfection Awaits; 08-14-2008 at 11:52 PM.

  19. #19
    getfitdoc
    Guest
    Quote Originally Posted by Perfection Awaits View Post
    I have done a ridiculous amount of research on this compound, and if anyone has any questions just post them up, or PM me. It is not recommended to run this without proper PCT, but some people do it anyways.
    PA
    just regular pct?

    It was better than Anavar (var) for you? Did you run Anavar (var) alone?

    estray Its good stuff. My wife ran it for a month. Put on around 5lbs got strong as hell.

    at about what dosage?

  20. #20
    estray
    Guest
    Quote Originally Posted by getfitdoc View Post
    at about what dosage?

    20mg per day

  21. #21
    Hi Perfection Awaits's Avatar
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    I used epi at 20mg for 2 weeks, then 30mg for the last 3 weeks. So one bottle last me a 5 week cycle. I was better than Anavar (var) for me. I ran my Anavar (var) standalone at 60mg ED. Regular post cycle therapy (pct) will be perfect. It is way easier for your body to bounce back from this compound than anything else. My post cycle therapy (pct) was just standard nolva 40/40/20/20, which i felt was more than enough, like i said above i havnt lost any of the strength or weight, and it's been 2 months since I ended.
    Last edited by Perfection Awaits; 08-15-2008 at 12:09 AM.

  22. #22
    getfitdoc
    Guest
    thanks guys,

    i ordered one bottle.

    I'll give it a shot, then i'll get some of my girls to try it.

  23. #23
    estray
    Guest
    Have fun. Great steroid for a woman imo.

  24. #24
    Hi Perfection Awaits's Avatar
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    Nice keep me updated. Sounds like a compound that would be safe for girls, as I imagine estray wouldnt have recommended it if it gave his wife a thicker beard than his

  25. #25
    getfitdoc
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    i've got some Anavar (var) , but i'll throw epi to one girl and Anavar (var) to the other, c what happens...

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