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  1. #1
    Junior Bodybuilder eagle_lex's Avatar
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    HCG mixing and dosage ???
    hey guys im getting ready to come off of a test cycle of 300mgs twice a week for the last 3 months. i have 10,000 units of Human Chorionic Gonadotropin (HCG). it came in one 10ml vial of solution and another vial of powder. do i mix all of the solution with the powder?? the dr. told me to only mix half of the solution and take 1cc every day for five days. is that correct?? im also going to run nolvadex post cycle after the Human Chorionic Gonadotropin (HCG).

    any and all suggestions are needed!! thanks again!

  2. #2
    Pro Bodybuilder DangerousGrounds's Avatar
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    Its best used mid long cycles or about 3 weeks after last injection of most tests
    Add the water to powder with the water given bro. After combining you need to refrigerate and it is good for about a month.

    A 10,000iu kit comes with 1cc (or ml.) of sterile water. Once you reconstitute, 10ius on an insulin point equals 1000ius and done 10iu points (slin pin).
    If no vial to put in preload slin pins and refrigerate.

    Reconstitute is when you combine water and powder in one.


    The the powder will just disolve when the water is mixed via syringe instantly..it should be the active powder.

    10ius on an insulin point equals 1000ius in typical Human Chorionic Gonadotropin (HCG) kit.....

    The IU units are on the pin and its translates in terms of slin iu points as follows for typical 10,000iu kit:

    a 10,000 iu kit if taken 5iu a day for 20 days=10,000..

    Thats how I dose a 10,000 iu kit 20 days, you will find it works very well spread out ED for 20 days.

    I personally get 29ga slin pins 1/3 cc per pin and fill 4 slin pins to 25 iu points,asuming you have 1 ml of water like most kits, and must be kept cold after mixing in fridge or freezer maybe in a box to conceil

    10ius on an insulin point equals 1000ius.....(on slin pin).
    5ius on slin pin=500iu of 10,000iu kit.
    thats assuming you used the 1 ml of bac water it came with.
    confusing hugh
    Last edited by DangerousGrounds; 01-31-2003 at 02:26 AM.

  3. #3
    Pro Bodybuilder DangerousGrounds's Avatar
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    HCG: This does nothing with regard to inhibition of the hypothalamus and pituitary. Rather it acts like LH, and causes the testicles to produce testosterone just as if LH were present. It is useful then for avoiding testicular atrophy during the cycle. The best dosing method is to use small amounts frequently: 500 IU per day is sufficient, and 1000 IU may optionally be used. The amount may be given as a single daily dose or divided into two doses. Administration may be intramuscular or subcutaneous. More is not better: too much Human Chorionic Gonadotropin (HCG) can result in downregulation of the LH receptors in the testes, and is therefore counterproductive. Overdosing of Human Chorionic Gonadotropin (HCG) can also result in gynecomastia.

    I personally would do ED for 20 days at 5 slin iu points and mix in conjuction with clomid.

  4. #4
    Junior Bodybuilder eagle_lex's Avatar
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    ok now im super confused!! i have only 23g 1.5 inch pins that hold 3cc. this will have to work! what do i do. how many ccs per shot if im going to do 20 shots? i guess that would be .5ccs, right??

  5. #5
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    hcg is not shot into the muscle, rather under the skin, not sure thAT THE PINS U HAVE ARE OK FOR THIS....

  6. #6
    Pro Bodybuilder DangerousGrounds's Avatar
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    a slin 29 ga unit is know wheres near a cc.
    I don't believe you can even measure correctly with a 3cc syringe as slin pins hold 30 ius and are only 1/3rd a cc.

  7. #7
    Junior Bodybuilder eagle_lex's Avatar
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    the vial says for IM use only. is that not intermuscular??

  8. #8
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    you can shoot Human Chorionic Gonadotropin (HCG) IM

  9. #9
    Junior Bodybuilder eagle_lex's Avatar
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    is one cc a day for five days sound right to you??

  10. #10
    Junior Bodybuilder mr.zone's Avatar
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    Originally posted by eagle_lex
    the vial says for IM use only. is that not intermuscular??
    Yes it does. take it intramuscular not subQ. If anyone can show me where it says you can take Human Chorionic Gonadotropin (HCG) subQ i'd like to see it.

    DESCRIPTION
    Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH). The beta sub-units of these hormones differ in amino acid sequence.

    PREGNYL® (chorionic gonadotropin for injection, USP) is a highly purified pyrogen-free preparation obtained from the urine of pregnant females. It is standardized by a biological assay procedure. It is available for intramuscular injection in multiple dose vials containing 10,000 USP Units of sterile dried powder with 5 mg monobasic sodium phosphate and 4.4 mg dibasic sodium phosphate. If required, pH is adjusted with sodium hydroxide and/or phosphoric acid. Each package also contains a 10 mL vial of solvent containing: water for injection with 0.56% sodium chloride and 0.9% BENZYL ALCOHOL, WHICH IS NOT FOR USE IN NEWBORNS. If required, pH is adjusted with sodium hydroxide and/or hydrochloric acid.

    CLINICAL PHARMACOLOGY
    The action of Human Chorionic Gonadotropin (HCG) is virtually identical to that of pituitary LH, although Human Chorionic Gonadotropin (HCG) appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.

    Androgen stimulation in the male leads to the development of secondary sex characteristics and may stimulate testicular descent when no anatomical impediment to descent is present. This descent is usually reversible when Human Chorionic Gonadotropin (HCG) is discontinued. During the normal menstrual cycle, LH participates with FSH in the development and maturation of the normal ovarian follicle, and the mid-cycle LH surge triggers ovulation. Human Chorionic Gonadotropin (HCG) can substitute for LH in this function.

    During a normal pregnancy, Human Chorionic Gonadotropin (HCG) secreted by the placenta maintains the corpus luteum after LH secretion decreases, supporting continued secretion of estrogen and progesterone and preventing menstruation. Human Chorionic Gonadotropin (HCG) HAS NO KNOWN EFFECT ON FAT MOBILIZATION, APPETITE OR SENSE OF HUNGER, OR BODY FAT DISTRIBUTION.

    INDICATIONS AND USAGE
    HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY. THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES WEIGHT LOSS BEYOND THAT RESULTING FROM CALORIC RESTRICTION, THAT IT CAUSES A MORE ATTRACTIVE OR “NORMAL” DISTRIBUTION OF FAT, OR THAT IT DECREASES THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIE-RESTRICTED DIETS.

    1. Prepubertal cryptorchidism not due to anatomical obstruction. In general, Human Chorionic Gonadotropin (HCG) is thought to induce testicular descent in situations when descent would have occurred at puberty. Human Chorionic Gonadotropin (HCG) thus may help predict whether or not orchiopexy will be needed in the future. Although, in some cases, descent following Human Chorionic Gonadotropin (HCG) administration is permanent, in most cases, the response is temporary. Therapy is usually instituted in children between the ages of 4 and 9.

    2. Selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males.

    3. Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins.

    CONTRAINDICATIONS
    Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG.

    WARNINGS
    HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for menotropins.

    The principal serious adverse reactions during this use are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion, (2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births, and (4) Arterial thromboembolism.

    PRECAUTIONS
    General
    Since androgens may cause fluid retention, Human Chorionic Gonadotropin (HCG) should be used with caution in patients with cardiac or renal disease, epilepsy, migraine, or asthma.

    Pediatric Use
    Induction of androgen secretion by Human Chorionic Gonadotropin (HCG) may induce precocious puberty in pediatric patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur.

    Geriatric Use
    Clinical studies of PREGNYL® (chorionic gonadotropin for injection, USP) did not include subjects aged 65 and over.

    ADVERSE REACTIONS
    Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, pain at the site of injection.

    DOSAGE AND ADMINISTRATION
    For intramuscular use only . The dosage regimen employed in any particular case will depend upon the indication for the use, the age and weight of the patient, and the physician’s preference. The following regimens have been advocated by various authorities:

    Prepubertal cryptorchidism not due to anatomical obstruction. Therapy is usually instituted in children between the ages of 4 and 9.

    4,000 USP Units three times weekly for three weeks.
    5,000 USP Units every second day for four injections.
    15 injections for 500 to 1,000 USP Units over a period of six weeks.
    500 USP Units three times weekly for four to six weeks. If this course of treatment is not successful, another series is begun one month later, giving 1,000 USP Units per injection.
    Selected cases of hypogonadotropic hypogonadism in males.

    500 to 1,000 USP Units three times a week for three weeks, followed by the same dose twice a week for three weeks.
    4,000 USP Units three times weekly for six to nine months, following which the dosage may be reduced to 2,000 USP Units three times weekly for an additional three months.
    Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins. (See prescribing information for menotropins for dosage and administration for that drug product.)

    5,000 to 10,000 USP Units one day following the last dose of menotropins. (A dosage of 10,000 USP Units is recommended in the labeling for menotropins.)

    Directions for Reconstitution
    Two-vial package: Withdraw sterile air from lyophilized vial and inject into diluent vial. Remove 1–10 mL from diluent and add to lyophilized vial; agitate gently until powder is completely dissolved in solution.

    Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

    IMPORTANT: USE COMPLETELY AFTER RECONSTITUTION. RECONSTITUTED SOLUTION IS STABLE FOR 60 DAYS WHEN REFRIGERATED.

    HOW SUPPLIED
    Two-vial package containing:
    — 1-10 mL lyophilized multiple dose vial containing: 10,000 USP Units chorionic gonadotropin per vial
    NDC 0052-0315-10.
    — 1-10 mL vial of solvent containing: water for injection with sodium chloride 0.56% and benzyl alcohol 0.9%
    NDC 0052-0325-10.


    When reconstituted, each 10 mL vial contains:
    Chorionic gonadotropin 10,000 USP Units
    Monobasic sodium phosphate 5 mg
    Dibasic sodium phosphate 4.4 mg
    Sodium chloride 0.56%
    Benzyl alcohol 0.9%
    If required pH adjusted with sodium hydroxide and/or phosphoric acid.

    Storage:
    Store at 15°–30°C (59°–86°F). Reconstituted solution is stable for 60 days when refrigerated

  11. #11
    Junior Bodybuilder mr.zone's Avatar
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    Originally posted by eagle_lex
    is one cc a day for five days sound right to you??
    I would run it 500ius ed for 2 weeks. I've never needed more then that. you should blow right back up in the first week.

  12. #12
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    Thanks MR ZONE
    I have been looking for this info for some time now....

  13. #13
    Junior Bodybuilder eagle_lex's Avatar
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    Originally posted by mr.zone
    I would run it 500ius ed for 2 weeks. I've never needed more then that. you should blow right back up in the first week.

    so is 500ius equal to .5cc?? i only have 3cc darts! thanks bro you da man!

  14. #14
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    that would be right, provided you mixed 10mls of liquid with the powder.

  15. #15
    Junior Bodybuilder mr.zone's Avatar
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    Originally posted by Vince2u2
    Thanks MR ZONE
    I have been looking for this info for some time now....
    no problem

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