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  1. #1
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    article: Why prolactin can ruin your day
    Last edited by macro; 02-15-2008 at 06:36 AM.

  2. #2
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    comments and questions appreciated

  3. #3
    Death Dealer ManOfMuscle's Avatar
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    Post it here pls.

  4. #4
    Pro Bodybuilder PeterPaul's Avatar
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    This is the second time you've posted an article that seems interesting, but I cant read.

  5. #5
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    The Anafit E-Zine Newsletter Ed1.vol 7
    Learning more about Prolactin
    By Mac Rophage
    “Why Prolactin Can Ruin Your Day”
    Most people have never heard of the peptide hormone, Prolactin. The name seems innocent enough, but this
    little neuroendocrine peptide can give you a whole of host of problems that you never thought possible.
    Prolactin’s primary job in the body is to aid in breast development, and, after pregnancy, Prolactin produces
    breast milk. Now if you are a man reading this article, you may be asking yourself, “Why would I have Prolactin
    problems?” Well, unfortunately, men and women are basically the same human template, and Prolactin
    production is part of life for both genders. Basically, 3 hormones play roles in both male and female bodies:
    Testosterone, Progesterone and Estrogen. It’s the varying amounts of these hormones, as well as the ratio they
    are produced in that really affects a great deal of the physiological and endrocrinological (hormonal) differences
    between men and women.
    So what effect does Prolactin, the peptide hormone, have on these three primary hormones in the human body?
    Prolactin production is adjusted in the body by all three of these hormones, however, Estrogen is the primary
    mastermind behind Prolactin production. Prolactin is basically a female hormone, but it does serve a purpose in
    men, though its purpose may not be considered beneficial by most men. For example, primary surges in
    Prolactin occurs after orgasm in males to let the male body know its “done”. In fact, the surge in Prolactin
    insures this feeling by immediately reducing sexual desire as well as erectile response. Basically, Prolactin acts
    as an “off” switch -- not exactly a beneficial function in most men’s minds, though surely there are women that
    are quite thankful for this biological hiatus. That being said, high Prolactin levels are a common cause of
    impotence and loss of sexual desire in both men and women.
    Sex is just one area where Prolactin may have negative effects on the body and mind. In addition to this,
    Prolactin also demands increases in food intake -- this is why the urge to raid the fridge after coitus is not
    uncommon. Studies in animals indicate that high Prolactin can increase food intake by as much as 20%. Studies
    with Prolactin suppressors in humans have shown significant decreases in food intake and fat loss, even where
    Prolactin levels are not considered to be “elevated”.
    For men, Prolactin presents an additional issue. It can cause and aggravate 'gynecomastia, which is the clinical
    term for female breast development in men. Prolactin’s effects on 'gynecomastia are worse when there is
    existing breast tissue from puberty and/or when there is high level of Estrogen present already. Also, as
    mentioned before, when high levels of Estrogen are present in this case, production of Prolactin in the body is
    further encouraged, thus compounding problems at hand and making the ordeal cyclic.

  6. #6
    Pro Bodybuilder PeterPaul's Avatar
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    Macro your thoughts on dostinex?

  7. #7
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    Quote Originally Posted by PeterPaul
    Macro your thoughts on dostinex?

    very effective prolactin suppressor, though reccomend cabaser (generic cabergoline/dostinex made in the same factory but A HELL OF A LOT cheaper).

  8. #8
    The Hot Mess Strega's Avatar
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    Macro, what is the typical dosage for guys like us that are attempting to control prolactin levels while using nandrolone. I just started a cycle and have Cabaser on hand, but am unsure of the dosages and frequency of dosing?

    Thanks in advance.

  9. #9
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    prevention .5mg e3d.
    treatment frontload 1mg/d for 3-5 with taper to .5mg ed then eod then go to prevention dose.

  10. #10
    Olympian Bodybuilder simpllyhuge's Avatar
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    Is there a way to test and correct the high prolactin surge after orgasm? I feel as thou I am totally unintrested in sex 100% after ejaculating and it stays like that for a very long time.

  11. #11
    Insane_Man
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    finding wet spots on your shirt around the nips will ruin your day, guranteed

  12. #12
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    Quote Originally Posted by simpllyhuge
    Is there a way to test and correct the high prolactin surge after orgasm? I feel as thou I am totally unintrested in sex 100% after ejaculating and it stays like that for a very long time.
    using dopaminergics, including short acting and dopamine modulators.

    cabaser
    bromocriptine
    selegiline
    l-dopa
    Neurogenex (may be used with any of the above or alone)
    vitex (at least in women- less research on men)
    macuna pruriens (l-dopa)

    note- staying cool during coitus MAY decrease the surge

  13. #13
    Amateur BB deltaboy14's Avatar
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    how long should you take cabaser or can you stay on it as long as you want

  14. #14
    Olympian Bodybuilder simpllyhuge's Avatar
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    can casaber or selegine increase hair loss. Also why is it that my body does this when I rarely hear of other men feeling this way so young.

  15. #15
    Amateur BB deltaboy14's Avatar
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    bro im the same way..i believe its due to prolactin levels so im gonna give cabaser a try

  16. #16
    Death Dealer ManOfMuscle's Avatar
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    Nice thread fellas. Good questions all around.

  17. #17
    Olympian Bodybuilder simpllyhuge's Avatar
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    i took casaber before and it didnt do much i dont think. ill try it again soon and see what happens. im curious what if i ejacualte before i go and get my blood taken? would that work lol

  18. #18
    Test E. baby! atomknight's Avatar
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    Good thead;
    How long dose one have to take caber?
    Forever,,,just after cycle...dose the prolatin levels clear up and not return or is it a constant mantiance

  19. #19
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    really depends on individual needs, generally just on cycle or when gyno symptoms present.

  20. #20
    Moderator juced_porkchop's Avatar
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    i herd Winstrol (winny) would help.. is that tru any 1 herd this??
    Follow me on Twitter for advanced in-depth peptide, supplement and AAS knowledge, along with all things bodybuilding! Follow me-> @Juced_porkchop

  21. #21
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    winstrol does have PgR antagonistic effects (primarily antagonistic), its effects on prolactin are unknown. Winstrol may help with gyno from other progestins (it does in some cases), however it can also worse symptoms (not enough is really known about its specific binding in this respect to draw a full conclusion as to why).

  22. #22
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  23. #23
    Pro Bodybuilder PeterPaul's Avatar
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    Macro, is there a rebound effect of any type? More prolactin after discontinuing Dostinex?

  24. #24
    Pro Bodybuilder raw lifter's Avatar
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    Figured i would add this for some extra reading...

    DOSTINEX
    THE SEX DRUG
    Dostinex (Also known as Cabergoline / Cabaser) is a relatively new drug Dostinex was primarily invented for the purpose of lowering prolactin in patients with a pituitary tumors and other prolactin related conditions. However it seems the potential of Dostinex goes far beyond the treatment of tumors. Dostinex can make sex better, much better for almost anyone, that’s the reason some refers to it as ‘The pleasure drug’ or the ‘Miracle drug’.

    So how's Dostinex different from Viagra?

    Dostinex is very different from Viagra. Viagra is a medication specifically for erectile dysfunction. Viagra will do absolutely nothing for other essential aspects of good sexual function such as libido (sex drive, arousal & excitement), orgasm and ejaculation.

    Viagra is a great medicine and has helped many men achieve erections, but that’s just part of what’s needed. Viagra is much like the erection you sometimes get when you wake up (aka “morning wood”). Viagra will just increase the blood flow in the penis causing an erection. It has nothing to do with libido, orgasm, ejaculation and other elements that constitute good sex. That’s the reason men complain that although they can have erections, sex is still not the same as it was when they were young. Why? Because their libido (sex drive) is much lower than it used to be when they were young.

    This is where Dostinex shines over Viagra. Dostinex does everything that Viagra doesn’t do. Dostinex improves libido, orgasm and ejaculation. Dostinex is a new drug from the dopaminergic family of drugs that decreases the hormone prolactin. Prolactin is the number one libido killer! Prolactin is the hormone that is also secreted in women after giving birth. That’s the reason women have extremely low or no sex drive at all after having given birth and for as long as they are breast feeding. Men with high levels of prolactin such as those that suffer from prolactinoma have no sex drive. As we age prolactin levels may become high for many perfectly healthy men, causing low sex drive.

    Prolactin is the same hormone is secreted immediately after ejaculation and makes you feel like ‘you don’t feel like anymore’. Its part of the reason you just want to go sleep after ejaculation with no will for another. Dostinex will decrease this hormone and increase your libido substantially. You’ll more likely feel like want to have sex and you may experience multiple orgasms as well as overwhelming orgasms and stronger ejaculations. High levels of prolactin were also shown to cause depression and affect well-being. By lowering prolactin, Dostinex may actually improve your well-being and generally make your ‘feel better’.

    Dostinex - The Sex Drug FAQ

    What is Dostinex?

    Dostinex (Also known as Cabergoline / Cabaser) is a relatively new drug Dostinex was primarily invented for the purpose of lowering prolactin in patients with a pituitary tumors and other prolactin related conditions. However it seems the potential of Dostinex goes far beyond the treatment of tumours. Dostinex can make sex better, much better for almost anyone, that’s the reason some refers to it as ‘The pleasure drug’ or the ‘Miracle drug’.

    How much Dostinex is needed for sex enhancement?

    Usually people report that half a tab every 4 days is enough to cause the desired increase in sex drive and libido. However, some prefer a full tab every 4 days. Keep in mind that Dostinex is not approved as a sexual enhancement tool, most medical studies about Dostinex were for treating patients with hyperprolactinemia.

    Dostinex is the pleasure drug of choice that can work for everybody and not just for people with sexual dysfunction. Dostinex may have the same sexualizing effect on women. This is due to the fact that Dostinex works on the primary sexual order: The brain! While Viagra may be useful for making an erection, Dostinex is useful for actually wanting the erection and enjoying it!

  25. #25
    Pro Bodybuilder raw lifter's Avatar
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    What do we think about this...Heart damage caused by Dostinex?? i've used it, but discontinued usage due to this article...


    taken from:

    http://news.yahoo.com/s/nm/20070104/...insons_drug_dc



    By Gene Emery and Toni Clarke Thu Jan 4, 8:21 AM ET

    BOSTON (Reuters) - Two Parkinson's disease drugs cause the same kind of heart damage that led to the withdrawal of the diet drug combination "fen-phen," according to two studies published on Wednesday.
    ADVERTISEMENT

    Patients taking the drugs pergolide, developed by Eli Lilly & Co. and sold under the brand name Permax, and cabergoline, developed by Pfizer Inc. and sold under the brand Dostinex, had a sharply higher risk of heart valve damage than those taking other therapies, the studies said.

    The studies, one of which analyzed the records of 11,417 patients in Britain and one of which tested 245 patients in Italy, reinforce the results of earlier, smaller studies showing drugs that activate a cellular receptor known as 5-HT2b can cause damage to the heart valve, a serious condition that can lead to heart failure and sudden death.

    "We recommend that physicians not prescribe drugs that have this biochemical property," said Bryan Roth, a researcher at the University of North Carolina, Chapel Hill, who was not involved in the trials, but viewed the data and commented on it in The
    New England Journal of Medicine, where both studies appeared.

    Michael Berelowitz, a Pfizer senior vice president, said cabergoline has very modest sales and is only approved in the United States for hyperprolactinemia -- a condition in which excessive amounts of the hormone prolactin enter the bloodstream due to benign tumors of the pituitary gland.

    He said benefits of the Pfizer drug, which is sold in Europe for Parkinson's disease, as well as hyperprolactinemia, outweigh the increased risk of heart valve damage, which is noted in the drug's package insert label.

    Lilly officials could not immediately be reached for comment.

    Such drugs also include the migraine headache drug ergotamine and the amphetamine derivative known as "ecstasy."

    Roth said his team, in a separate piece of research that has yet to be published or reviewed by the scientific community, has identified several other big-selling drugs that have until now not been known to activate the 5-HT2b receptor.

    He declined to reveal the names of the drugs until the research has been published.

    "We recommend that every drug be screened at this receptor before it goes into humans," Roth told Reuters in an interview. "It costs just pennies per drug for such a screen."

    The British study showed patients taking pergolide were 7.1 times more likely to develop heart valve damage than those who took other treatments. Patients taking the highest doses of the drug had a 37 times greater risk.

    The study showed patients taking cabergoline were 4.9 times more likely to develop heart valve damage. At higher doses patients were 50.3 times more likely to suffer damage.

    Both drugs are available in generic form.

    A second study, conducted in Italy, tested 245 people, of whom 155 had Parkinson's disease. Of the diseased population, one group received pergolide, one group received cabergoline and one group received an alternative Parkinson's treatment. The non-diseased control group received nothing.

    The results showed that 23.4 percent of patients taking pergolide and 28.6 percent of patients taking cabergoline suffered heart damage, compared with just 5.6 percent in the control group.

    "These are huge risks," said Roth.

    He added they were similar to the kind of damage seen with fen-phen, whose main ingredients were withdrawn in 1997 and forced the drug-maker Wyeth to take more than $21 billion in charges to cover liabilities.

    Wyeth's recalled drugs were fenfluramine, or Pondimin, and dexfenfluramine, or Redux. To make fen-phen, one or the other was combined with another drug called phentermine that is still sold by other companies.

    Wyeth, then called American Home Products, recalled Pondimin and Redux after some of the 6 million Americans who had taken fen-phen developed heart-valve problems.

    Roth said pergolide is also used to treat restless leg syndrome, a condition in which patients feel a crawling sensation in their legs combined with a need to move them.

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