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(Forum for members to discuss the use of anabolic steroids)

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  1. #1
    Pro Bodybuilder pineapple's Avatar
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    Default Dostinex and heart valve damage
    Just saw this on a commercial, one of those lawyer commercials advertising if you got damage from Dostinex you can get monitary compensation. Something about dostinex causing heart valve damage.

  2. #2
    Senior Member outlawtas's Avatar
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    I believe the dosages and durations where significantly larger than that BB'ers would run. I'd rather just use B6 to combat gyno.

    Warning: Cabergoline/Dostinex users!
    Last edited by outlawtas; 04-21-2007 at 01:55 PM.

  3. #3
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    ....
    Quote Originally Posted by macro
    cabaser has never been linked to any heart problems at the dosage used for treatment of hyperprolactinemia.

    the dosage it has been linked to heart problems, which is the dosage used for parkinsons and is 6 plus mg per day, is 12 to 48 times the dosage used for prolactin issues.

    its a bit like saying dont take caffeine (600mg/day) because at 7.2 grams per day to 28.8grams per day it causes heart problems or "z".

    or dont take your 20mg of adderal because 240mg to 960mg has been linked to "x" (you pick the condition)

    or dont take 1mg of letro because 12 to 48 mg of letro per day has been linked to "y".

    or 100mg of anadrol vs. 1200mg to 4.8grams of anadrol...etc..
    Stone Cold..............................Never Too Old



    Disclaimer: Steroidology.com does not promote the use of anabolic steroids without a doctor's prescription. The information we share is for entertainment purposes only.

  4. #4
    Pro Bodybuilder pineapple's Avatar
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    Gotcha, didnt realize the dose related consequences.

  5. #5
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    dose is often everything, 5ht2 receptors are the cause of the heart issues. at lower doses there is nearly no interaction with this receptor since it has high affinity for the D2, as the dosage increases interaction with this and other receptors increases. basically its an affinity v. concentration issue. if you increase the concentration eventually you get binding.

    for instance testosterone at high enough dosages binds to the estrogen receptor

  6. #6
    Senior Member outlawtas's Avatar
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    Good to know SC/Marco. It was concerning for a while, especially with all the lawsuits.

  7. #7
    Death Dealer ManOfMuscle's Avatar
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    I wish to electronically link up to macro's brain and upload all the information. How much would that cost?

  8. #8
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    Quote Originally Posted by outlawtas2
    Good to know SC/Marco. It was concerning for a while, especially with all the lawsuits.

    well with over 500,000 sufferers of parkinsons in the US alone, there are likely a lot of people who received the high dose treatment

  9. #9
    Olympian Bodybuilder HeHateMe's Avatar
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    Quote Originally Posted by LiftTillIDie
    I wish to electronically link up to macro's brain and upload all the information. How much would that cost?
    Sign me up too. The man definitely knows his stuff...

  10. #10
    A Legend GymLift's Avatar
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    Why should the drug manufacturer be liable for a side effect that they nor nobody else knew about, despite millions and millions of dollars they invested into clinical studies?

  11. #11
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    they knew or should have known that at those high doses there would be 5ht2 binding, which they should have known from the research on 5ht2 might cause issues. And its hard to say what they really knew, it would not be the first time where research was not released or watered down.

    cabergoline is a massively profitable drug, with those high doses and with a large population like that, its easy to see how corners might be cut or issues overlooked.

  12. #12
    Senior Member roccodart440's Avatar
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    WHat is a high dose macro? I think I was taing .5mg EW or so.

    ALso B6 may be great for comabtting prlatin incduced gyno but what about sexual side effects? Enter cabergoline.

  13. #13
    A Legend GymLift's Avatar
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    Quote Originally Posted by macro
    they knew or should have known that at those high doses there would be 5ht2 binding, which they should have known from the research on 5ht2 might cause issues. And its hard to say what they really knew, it would not be the first time where research was not released or watered down.
    Take a look at the package insert for Dostinex:

    http://www.pfizer.com/pfizer/download/uspi_dostinex.pdf

    The max dosage stated is 1mg twice/week, much less than 6g/day.

    If physicians prescribed more, then they decided to go against the instructions from the manufacturer, endorsed by the FDA.

    But the thing is; the overall community of physicians decided that prescribing more way ok. Did they not know that 5ht2 binding might cause this problem? Or perhaps they decided that the benefit was much greater than the risk? That would certainly be reasonable.

    I've heard called to have Dostinex removed from the market, thereby removing it as an option for physicians and patients that consider it to be well worth the risk. I reject the notion that this drug should be removed from the market.

  14. #14
    Death Dealer ManOfMuscle's Avatar
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    Quote Originally Posted by roccodart440
    WHat is a high dose macro? I think I was taing .5mg EW or so.

    ALso B6 may be great for comabtting prlatin incduced gyno but what about sexual side effects? Enter cabergoline.
    Since b6 works to block prolactin I would think it would have at least no harmful effect on your sex drive, if not a positive one.

  15. #15
    A Legend GymLift's Avatar
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    Quote Originally Posted by LiftTillIDie
    Since b6 works to block prolactin I would think it would have at least no harmful effect on your sex drive, if not a positive one.
    I'll assume that by 'block prolactin' you mean 'reduces prolactin production'. In this case, I agree with you.

    When I'm expecting a special evening (or day), I load up no B6.

    I would use Dostinex but the shits too damn expensive for me.

  16. #16
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    Quote Originally Posted by mranak

    I would use Dostinex but the shits too damn expensive for me.
    cabaser tabs
    20 tabs 1mg 75$
    aurapharm

  17. #17
    Death Dealer ManOfMuscle's Avatar
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    Quote Originally Posted by macro
    cabaser tabs
    20 tabs 1mg 75$
    aurapharm
    That is spendy.

  18. #18
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    20 of the 1mg tabs will last you 3-4 months.

  19. #19
    Death Dealer ManOfMuscle's Avatar
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    Quote Originally Posted by macro
    20 of the 1mg tabs will last you 3-4 months.
    Ah I was factoring it at a bout .5 mg eod. I guess you don't need that much.

  20. #20
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    Default cabaser
    hi macro
    i have bought 16 tabs a 4 mg, would you think it is dangerous to take
    maybe 1 tab every two weeks. when i took one i felt nothing problematic
    just the libido worked well.
    greetings from germany

  21. #21
    A Legend GymLift's Avatar
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    Quote Originally Posted by stupidman
    hi macro
    i have bought 16 tabs a 4 mg, would you think it is dangerous to take
    maybe 1 tab every two weeks. when i took one i felt nothing problematic
    just the libido worked well.
    greetings from germany
    You need to get a pill cutter and split those pills up into as small of pieces as you can.

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