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Originally Posted by macro
Clomid is superior in every way in restoring the HPGA.
Nolva appears to be only effective if you are not heavily suppressed, it does not stimulate LH release but mainly acts as priming agent for response to GnRH. Also it upregulates the PgR (this is via estrogenic as well as theorized non-genomic action) which can exacerbate gyno issues when progestins are involved. Nolva is commonly linked to post cycle gyno for this reason.
tamoxifen upregulates inhibin as well.
this is not to say that some people cannot use nolva with positive results, merely that both the clinical and anecdotal evidence are against it for use among the general population.
however that being said a lot is not known about the AAS suppressed state (which has a number of actors of which E is primary but certainly not alone).
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Tamoxifen has been shown to be quite effective for elevating gonadotropins. I have used it many times for this purpose, when I had to. I do prefer Clomid, though, UNLESS THERE ARE UNTOWARD SIDE EFFECTS (which we don't see with tamoxifen). In fact, as Dr. Shippen and I have independently found, just 25mg QD of Clomid is a very effective dose for restoring the HPTA.
Have you seen any studies with respect to Clomid and
PR regulation?
Some claim tamoxifen is taxonimized incorrectly as a SERM, that it is a pure estrogen antagonist. I'm still thinking about that one. But its effects with respect to
PR regulation is an important consideration there.